Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | SSTR3 | P32745 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9912090 | 0.73 | CDC7 (0.37) | CHRNA7HTR3A | |
| SCHEMBL15692802 | 0.71 | SCN10A (0.36) | CHRNA7SSTR3KCNH2 | |
| SCHEMBL5107232 | 0.69 | KCNH2 (0.50) | CHRNA7CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL5113459 | 0.68 | CHRNA7 (0.35) | CHRNA7CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL9977178 | 0.66 | SCN10A (0.42) | SSTR3KCNH2 | |
| SCHEMBL4989041 | 0.66 | HTR3A (0.42) | HTR3A | |
| SCHEMBL4989050 | 0.66 | HTR3A (0.42) | HTR3A | |
| SCHEMBL16580636 | 0.66 | HPGDS (0.44) | KCNH2 | |
| SCHEMBL9912036 | 0.66 | HPGDS (0.44) | KCNH2 | |
| SCHEMBL13731619 | 0.65 | HTR3A (0.64) | CHRNA7HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080188518-A1 | 5-Substituted Imidazoles | ASTRA ZENECA AB (SE) | 2008-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080188518-A1 | 5-Substituted Imidazoles | GABRA5, GRIN2C, GABRE | CHRNA7 71/4885HTR3A 572/4885CHRM2 237/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.