Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 8/20 | 0.49 |
| ▸ | TSHR | P16473 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5003384 | 0.90 | LMNA (0.51) | LMNATSHRSMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL5003048 | 0.83 | ALDH1A1 (0.53) | LMNATSHRSMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL5003199 | 0.82 | ALDH1A1 (0.48) | LMNATSHRSMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL4996733 | 0.81 | MAPT (0.51) | LMNATSHRSMN1; SMN2L3MBTL1ALDH1A1 | |
| SCHEMBL4996877 | 0.80 | NPC1 (0.45) | SMN1; SMN2ALDH1A1MAPTMAPK1MEN1 | |
| SCHEMBL4993330 | 0.80 | CHEK1 (0.57) | LMNASMN1; SMN2ALDH1A1MAPTMEN1 | |
| SCHEMBL4997188 | 0.79 | HRH3 (0.53) | LMNAL3MBTL1ALDH1A1MAPTMAPK1 | |
| SCHEMBL5003418 | 0.78 | CHEK1 (0.55) | LMNASMN1; SMN2ALDH1A1MAPTMEN1 | |
| SCHEMBL5000689 | 0.78 | MAPT (0.53) | LMNATSHRSMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL4996829 | 0.78 | ALDH1A1 (0.50) | LMNATSHRSMN1; SMN2L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194574-A1 | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases | AXXIMA PHARMACEUTICALS AG (DE) | 2008-08-14 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194574-A1 | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases | PRNP, PSEN1, PPP5C | LMNA 2743/4885TSHR 2332/4885SMN1; SMN2 896/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.