Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 5/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | F11 | P03951 | 1/20 | 0.31 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.30 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.30 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.30 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.30 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.30 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3332246 | 0.93 | REN (0.47) | RENCYP3A4HPGDF11KLKB1 | |
| SCHEMBL8083205 | 0.90 | REN (0.54) | RENCYP3A4HPGD | |
| SCHEMBL498963 | 0.90 | REN (0.44) | RENCYP3A4 | |
| SCHEMBL498863 | 0.90 | REN (0.44) | RENCYP3A4 | |
| SCHEMBL498864 | 0.90 | REN (0.44) | RENCYP3A4 | |
| SCHEMBL499595 | 0.88 | REN (0.54) | RENCYP3A4 | |
| SCHEMBL499157 | 0.86 | REN (0.52) | RENCYP3A4 | |
| SCHEMBL3336471 | 0.84 | REN (0.48) | RENCYP3A4 | |
| SCHEMBL3336109 | 0.84 | REN (0.48) | RENCYP3A4 | |
| SCHEMBL3335146 | 0.84 | REN (0.48) | RENCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106221-B2 | Renin inhibitors | VITAE PHARMACEUTICALS, INC. (US) | 2012-01-31 | — | — | US | claimed |
| US-8106221-B2 | Renin inhibitors | VITAE PHARMACEUTICALS, INC. (US) | 2012-01-31 | — | — | US | disclosed |