Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.45 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.44 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.44 |
| ▸ | SPR | P35270 | 9/20 | 0.44 |
| ▸ | EIF4A3 | P38919 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4982582 | 0.81 | ALDH1A1 (0.54) | ALDH1A1P2RX7HTT | |
| SCHEMBL14272340 | 0.79 | TSHR (0.48) | ALDH1A1MAPK1MAPTNPSR1P2RX7 | |
| SCHEMBL4987112 | 0.79 | ALDH1A1 (0.41) | ALDH1A1MAPK1MAPTNPSR1SLC9A1 | |
| SCHEMBL4985624 | 0.78 | P2RX7 (0.49) | ALDH1A1P2RX7 | |
| SCHEMBL13532531 | 0.78 | ALDH1A1 (0.40) | ALDH1A1MAPK1MAPTNPSR1P2RX7 | |
| SCHEMBL4986740 | 0.77 | KDM4E (0.47) | ALDH1A1MAPTP2RX7LMNAHTT | |
| SCHEMBL4982574 | 0.77 | P2RX7 (0.40) | ALDH1A1MAPK1MAPTNPSR1P2RX7 | |
| SCHEMBL4989133 | 0.76 | P2RX7 (0.62) | ALDH1A1P2RX7LMNAHTT | |
| SCHEMBL4986230 | 0.76 | P2RX7 (0.51) | ALDH1A1P2RX7 | |
| SCHEMBL4988102 | 0.76 | HTT (0.50) | ALDH1A1P2RX7HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080039478-A1 | Bicycloheteroaryl Compounds as P2X7 Modulators and Uses Thereof | RENOVIS, INC. | 2008-02-14 | — | — | US | claimed |
| US-7297700-B2 | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof | RENOVIS, INC. (US) | 2007-11-20 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039478-A1 | Bicycloheteroaryl Compounds as P2X7 Modulators and Uses Thereof | P2RX7, P2RX3, P2RX2 | ALDH1A1 3640/4885MAPK1 546/4885MAPT 4477/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.