Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | PIM2 | Q9P1W9 | 8/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | PIM1 | P11309 | 1/20 | 0.48 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4996178 | 0.90 | PIM2 (0.52) | PIM2PIM1CSNK2A2CSNK2A1SLC6A7 | |
| SCHEMBL4997188 | 0.89 | HRH3 (0.53) | POLBALDH1A1MAPK1SLC6A7L3MBTL1 | |
| SCHEMBL4995128 | 0.86 | PIM2 (0.55) | PIM2PIM1CSNK2A2CSNK2A1MAPK1 | |
| SCHEMBL4997769 | 0.85 | PIM2 (0.52) | PIM2PIM1CSNK2A2CSNK2A1SMN1; SMN2 | |
| SCHEMBL5003434 | 0.84 | ACHE (0.57) | POLBPIM2HPGDALDH1A1MAPK1 | |
| SCHEMBL5003397 | 0.83 | SMN1; SMN2 (0.53) | PIM2PIM1CSNK2A2CSNK2A1ALDH1A1 | |
| SCHEMBL3364833 | 0.82 | PIM2 (0.68) | PIM2PIM1CSNK2A2CSNK2A1 | |
| SCHEMBL4997412 | 0.81 | KMT2A (0.55) | PIM2HPGDALDH1A1MAPK1KDM4E | |
| SCHEMBL5003444 | 0.81 | DRD4 (0.49) | POLBPIM2HPGDALDH1A1MAPK1 | |
| SCHEMBL5002971 | 0.81 | PIM2 (0.50) | PIM2HPGDPIM1CSNK2A2CSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194574-A1 | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases | AXXIMA PHARMACEUTICALS AG (DE) | 2008-08-14 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194574-A1 | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases | PRNP, PSEN1, PPP5C | POLB 889/4885PIM2 1679/4885HPGD 1494/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.