Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | PIM2 | Q9P1W9 | 9/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4997581 | 0.90 | PIM2 (0.48) | SMN1; SMN2ALDH1A1PIM2KMT2APIM1 | |
| SCHEMBL5003048 | 0.89 | ALDH1A1 (0.53) | SMN1; SMN2ALDH1A1PIM2NPSR1MAPK1 | |
| SCHEMBL5003384 | 0.85 | LMNA (0.51) | SMN1; SMN2ALDH1A1PIM2MEN1KMT2A | |
| SCHEMBL4995128 | 0.84 | PIM2 (0.55) | SMN1; SMN2PIM2MAPK1HSD17B10PIM1 | |
| SCHEMBL4994571 | 0.84 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1PIM2NPSR1MAPK1 | |
| SCHEMBL4994141 | 0.83 | POLB (0.55) | SMN1; SMN2ALDH1A1PIM2MAPK1MEN1 | |
| SCHEMBL4997488 | 0.82 | LMNA (0.50) | SMN1; SMN2ALDH1A1PIM2NPSR1MAPK1 | |
| SCHEMBL4997769 | 0.81 | PIM2 (0.52) | SMN1; SMN2PIM2PIM1CSNK2A2CSNK2A1 | |
| SCHEMBL4996178 | 0.81 | PIM2 (0.52) | PIM2PIM1CSNK2A2CSNK2A1 | |
| SCHEMBL3364833 | 0.81 | PIM2 (0.68) | PIM2PIM1CSNK2A2CSNK2A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194574-A1 | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases | AXXIMA PHARMACEUTICALS AG (DE) | 2008-08-14 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194574-A1 | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases | PRNP, PSEN1, PPP5C | SMN1; SMN2 896/4885ALDH1A1 1034/4885PIM2 1679/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.