Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM2 | Q9P1W9 | 8/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | RAD52 | P43351 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5000689 | 0.91 | MAPT (0.53) | PIM2MAPTHTTLMNARXFP1 | |
| SCHEMBL4995128 | 0.90 | PIM2 (0.55) | PIM2MAPTPIM1CSNK2A2CSNK2A1 | |
| SCHEMBL5003109 | 0.87 | ALDH1A1 (0.55) | PIM2MAPTPIM1CSNK2A2CSNK2A1 | |
| SCHEMBL4997769 | 0.87 | PIM2 (0.52) | PIM2PIM1CSNK2A2CSNK2A1RAD52 | |
| SCHEMBL4997430 | 0.85 | RAF1 (0.51) | PIM2MAPTHTTPIM1CSNK2A2 | |
| SCHEMBL5000893 | 0.85 | ABCG2 (0.52) | PIM2MAPTLMNARXFP1MEN1 | |
| SCHEMBL4997580 | 0.83 | CHEK1 (0.57) | PIM2 | |
| SCHEMBL4992241 | 0.83 | ALDH1A1 (0.53) | PIM2MAPTRAD52KDM4EMEN1 | |
| SCHEMBL4996178 | 0.82 | PIM2 (0.52) | PIM2PIM1CSNK2A2CSNK2A1RAD52 | |
| SCHEMBL4993619 | 0.82 | DHFR (0.46) | PIM2MAPTRAD52MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194574-A1 | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases | AXXIMA PHARMACEUTICALS AG (DE) | 2008-08-14 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194574-A1 | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases | PRNP, PSEN1, PPP5C | PIM2 1679/4885MAPT 5/4885HTT 347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.