Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | RAD52 | P43351 | 1/20 | 0.43 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5000665 | 0.85 | NPC1 (0.50) | RAD52DHFRALDH1A1MAPTPIM2 | |
| SCHEMBL4987417 | 0.85 | RAD52 (0.45) | RAD52ALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL4995459 | 0.82 | CYP11B1 (0.48) | BRAFCHEK1CYP11B1CYP11B2RAD52 | |
| SCHEMBL5000876 | 0.81 | ALDH1A1 (0.43) | RAD52ALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL4994661 | 0.80 | ACVR1 (0.42) | RAD52MAPTKCNH2TNIKHTR7 | |
| SCHEMBL4994280 | 0.80 | MAP4K1 (0.45) | CHEK1ALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL4996131 | 0.79 | FYN (0.43) | CYP11B1CYP11B2ALDH1A1LMNAMAPT | |
| SCHEMBL4993234 | 0.78 | RAD52 (0.42) | CHEK1RAD52LMNAMAPTPIM2 | |
| SCHEMBL5000890 | 0.78 | ALDH1A1 (0.45) | CHEK1CYP11B1CYP11B2ALDH1A1LMNA | |
| SCHEMBL4997510 | 0.78 | MAPT (0.60) | ALDH1A1LMNAMAPTHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194574-A1 | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases | AXXIMA PHARMACEUTICALS AG (DE) | 2008-08-14 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194574-A1 | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases | PRNP, PSEN1, PPP5C | BRAF 478/4885CHEK1 1668/4885CYP11B1 132/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.