Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Benzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 2/20 | 0.72 |
| ▸ | CCR1 | P32246 | 1/20 | 0.72 |
| ▸ | CCR5 | P51681 | 5/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.39 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1950538 | 0.94 | CCR1 (0.80) | ABCB11CCR1CCR5SIGMAR1MAOB | |
| Sulfuric Acid SCHEMBL1952168 | 0.91 | CCR1 (0.76) | ABCB11CCR1CCR5SIGMAR1MEN1 | |
| Azd4818 SCHEMBL2061809 | 0.90 | CCR1 (0.88) | ABCB11CCR1CCR5SIGMAR1MAOB | |
| SCHEMBL4998454 | 0.90 | CCR1 (0.68) | ABCB11CCR1CCR5SIGMAR1MAOB | |
| SCHEMBL4668083 | 0.89 | ABCB11 (0.73) | ABCB11CCR1CCR5SIGMAR1MAOB | |
| SCHEMBL4666529 | 0.89 | ABCB11 (0.73) | ABCB11CCR1CCR5SIGMAR1MAOB | |
| SCHEMBL4666533 | 0.88 | ABCB11 (0.61) | ABCB11CCR1CCR5SIGMAR1MAOB | |
| SCHEMBL3675985 | 0.86 | CCR1 (0.68) | ABCB11CCR1CCR5SIGMAR1MEN1 | |
| SCHEMBL3810728 | 0.84 | ABCB11 (1.00) | ABCB11CCR1CCR5SIGMAR1MEN1 | |
| SCHEMBL3807493 | 0.84 | ABCB11 (1.00) | ABCB11CCR1CCR5SIGMAR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194632-A1 | Novel Piperidine Derivatives as Chemokine Receptor Modulators Useful for the Treatment of Respiratory Diseases | ASTRAZENECA AB (SE) | 2008-08-14 | — | — | US | claimed |
| US-20080194632-A1 | Novel Piperidine Derivatives as Chemokine Receptor Modulators Useful for the Treatment of Respiratory Diseases | ASTRAZENECA AB (SE) | 2008-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194632-A1 | Novel Piperidine Derivatives as Chemokine Receptor Modulators Useful for the Treatment of Respiratory Diseases | ACKR3, CCR5, CCR2 | ABCB11 760/4885CCR1 4/4885CCR5 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.