Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 9/20 | 0.39 |
| ▸ | PIM3 | Q86V86 | 7/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CTSA | P10619 | 2/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 5/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | ECE1 | P42892 | 1/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30448183 | 0.83 | ALDH1A1 (0.55) | PIM1PIM3ALDH1A1CTSAPIM2 | |
| SCHEMBL3536356 | 0.83 | ALDH1A1 (0.55) | PIM1PIM3ALDH1A1CTSAPIM2 | |
| SCHEMBL4999401 | 0.74 | PIM1 (0.37) | PIM1PIM3ALDH1A1CTSAPIM2 | |
| SCHEMBL29600613 | 0.70 | MAOA (0.57) | PIM1PIM3PIM2 | |
| SCHEMBL319326 | 0.69 | PIM1 (0.56) | PTGER1PIM1PIM3ALDH1A1PIM2 | |
| SCHEMBL3538488 | 0.69 | TRPC3 (0.48) | PIM1PIM3PIM2KDM4EHPGD | |
| SCHEMBL2694760 | 0.69 | ALDH1A1 (0.59) | PIM1PIM3ALDH1A1PIM2KDM4E | |
| SCHEMBL26319783 | 0.69 | ALDH1A1 (0.55) | ALDH1A1CTSAIRAK4KDM4EHPGD | |
| SCHEMBL29600625 | 0.69 | ALDH1A1 (0.59) | PIM1PIM3ALDH1A1PIM2KDM4E | |
| SCHEMBL3540061 | 0.68 | PIM1 (0.44) | PIM1PIM3PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979335-A2 | THIAZOLES AS 11 BETA-HSD1 INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-10-15 | — | — | EP | disclosed |
| WO-2007082808-A2 | THIAZOLES AS 11 BETA-HSD1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-07-26 | — | — | WO | disclosed |