Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.57 |
| ▸ | ACHE | P22303 | 1/20 | 0.57 |
| ▸ | PIM1 | P11309 | 19/20 | 0.55 |
| ▸ | PIM3 | Q86V86 | 15/20 | 0.55 |
| ▸ | PIM2 | Q9P1W9 | 13/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25379771 | 0.87 | ACHE (0.70) | MAOAACHEPIM1PIM3 | |
| SCHEMBL318924 | 0.85 | RAB9A (0.57) | PIM1PIM3PIM2 | |
| SCHEMBL15608880 | 0.84 | ACHE (0.52) | MAOAACHEPIM1PIM3PIM2 | |
| SCHEMBL11912168 | 0.83 | PIM1 (0.55) | PIM1PIM3PIM2 | |
| SCHEMBL15609179 | 0.83 | MAOA (0.51) | MAOAACHEPIM1PIM3 | |
| SCHEMBL29599831 | 0.82 | PIM1 (0.50) | MAOAACHEPIM1PIM3PIM2 | |
| SCHEMBL26319786 | 0.82 | MAOA (0.57) | MAOAACHEPIM1PIM3 | |
| SCHEMBL319326 | 0.81 | PIM1 (0.56) | ACHEPIM1PIM3PIM2 | |
| SCHEMBL14656020 | 0.81 | ACHE (0.64) | MAOAACHE | |
| SCHEMBL2554961 | 0.80 | PIM1 (0.62) | ACHEPIM1PIM3PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108715590-B | Thiazolecarboxamide and picolinamide compounds useful as PIM kinase inhibitors | 因赛特公司 | 2022-03-08 | — | — | CN | disclosed |