Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.53 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.53 |
| ▸ | RAD52 | P43351 | 1/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 8/20 | 0.43 |
| ▸ | AKT1 | P31749 | 8/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.43 |
| ▸ | PIM1 | P11309 | 2/20 | 0.43 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 3/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4992156 | 0.81 | CYP11B1 (0.49) | CYP11B1CYP11B2RAD52PIM2PIM1 | |
| SCHEMBL4992873 | 0.80 | RAD52 (0.52) | CYP11B1CYP11B2RAD52PIM2PIM1 | |
| SCHEMBL5003086 | 0.80 | CYP11B1 (0.47) | CYP11B1CYP11B2RAD52PIM2PIM1 | |
| SCHEMBL5000719 | 0.80 | CYP11B1 (0.47) | CYP11B1CYP11B2RAD52PIM2PIM1 | |
| SCHEMBL4997662 | 0.78 | CYP11B1 (0.46) | CYP11B1CYP11B2RAD52PIM2PIM1 | |
| SCHEMBL4992899 | 0.77 | CYP11B1 (0.45) | CYP11B1CYP11B2PIM2PIM1PIM3 | |
| SCHEMBL5003013 | 0.76 | CYP11B2 (0.60) | CYP11B1CYP11B2PIM2PIM1PIM3 | |
| SCHEMBL5003151 | 0.75 | MAPT (0.50) | CYP11B1CYP11B2 | |
| SCHEMBL5000887 | 0.75 | CHEK1 (0.47) | CYP11B1CYP11B2PIM2 | |
| SCHEMBL5003298 | 0.75 | MAPT (0.44) | CYP11B1CYP11B2PIM2PIM1PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194574-A1 | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases | AXXIMA PHARMACEUTICALS AG (DE) | 2008-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194574-A1 | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases | PRNP, PSEN1, PPP5C | CYP11B1 132/4885CYP11B2 112/4885RAD52 1663/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.