Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 1/20 | 0.52 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.47 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.45 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.45 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4993263 | 0.82 | MAPT (0.47) | RAD52CYP11B1CYP11B2ROCK2ROCK1 | |
| SCHEMBL4995513 | 0.80 | PIM2 (0.56) | RAD52CYP11B1CYP11B2ROCK2ROCK1 | |
| SCHEMBL5000472 | 0.80 | CYP11B1 (0.53) | RAD52CYP11B1CYP11B2ROCK2ROCK1 | |
| SCHEMBL4992059 | 0.80 | POLB (0.51) | CYP11B1CYP11B2ROCK2ROCK1CSNK1D | |
| SCHEMBL4995140 | 0.80 | CSNK1D (0.49) | RAD52CYP11B1CYP11B2ROCK2ROCK1 | |
| SCHEMBL4996961 | 0.78 | MEN1 (0.51) | RAD52CYP11B1CYP11B2ROCK2ROCK1 | |
| SCHEMBL5003429 | 0.78 | KDM4E (0.51) | RAD52CYP11B1CYP11B2ROCK2ROCK1 | |
| SCHEMBL5000701 | 0.78 | LMNA (0.51) | RAD52CYP11B1CYP11B2ROCK2ROCK1 | |
| SCHEMBL3649334 | 0.77 | DKK1 (0.61) | RAD52CYP11B1CYP11B2ROCK2ROCK1 | |
| SCHEMBL4994785 | 0.76 | SLC6A2 (0.47) | RAD52PIM2SLC6A2SLC6A4DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194574-A1 | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases | AXXIMA PHARMACEUTICALS AG (DE) | 2008-08-14 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194574-A1 | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases | PRNP, PSEN1, PPP5C | RAD52 1663/4885CYP11B1 132/4885CYP11B2 112/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.