Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | RAC1 | P63000 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4996131 | 0.91 | FYN (0.43) | ALDH1A1NPC1RAB9ASMN1; SMN2MAP4K1 | |
| SCHEMBL4995371 | 0.87 | HTR7 (0.43) | ALDH1A1NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL5000665 | 0.87 | NPC1 (0.50) | ALDH1A1NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL4997668 | 0.87 | NPC1 (0.58) | ALDH1A1NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL4994280 | 0.85 | MAP4K1 (0.45) | ALDH1A1SMN1; SMN2KDM4EHTR7MAP4K1 | |
| SCHEMBL4987417 | 0.85 | RAD52 (0.45) | ALDH1A1NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL5000621 | 0.85 | MAP4K1 (0.43) | ALDH1A1SMN1; SMN2KDM4EHTR7MAP4K1 | |
| SCHEMBL4997627 | 0.84 | NPC1 (0.55) | ALDH1A1NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL5000890 | 0.84 | ALDH1A1 (0.45) | ALDH1A1NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL5003394 | 0.83 | HTR3A (0.44) | NPC1HTR3ARAD52DRD4CSNK1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194574-A1 | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases | AXXIMA PHARMACEUTICALS AG (DE) | 2008-08-14 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194574-A1 | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases | PRNP, PSEN1, PPP5C | ALDH1A1 1034/4885NPC1 2008/4885RAB9A 2969/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.