Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 6/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | XIAP | P98170 | 1/20 | 0.39 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4444348 | 0.98 | OPRL1 (0.47) | OPRL1HSD11B1PLD1KCNH2OPRM1 | |
| SCHEMBL4438978 | 0.89 | PLD1 (0.43) | OPRL1HSD11B1PLD1KCNH2OPRM1 | |
| SCHEMBL4436741 | 0.89 | PLD1 (0.43) | OPRL1HSD11B1PLD1KCNH2OPRM1 | |
| SCHEMBL4440120 | 0.89 | OPRM1 (0.42) | OPRL1HSD11B1PLD1KCNH2OPRM1 | |
| Hydrochloric Acid SCHEMBL4439105 | 0.88 | PLD1 (0.42) | OPRL1HSD11B1PLD1KCNH2OPRM1 | |
| SCHEMBL4443247 | 0.87 | PLD1 (0.43) | OPRL1HSD11B1PLD1KCNH2OPRM1 | |
| Sulfuric Acid SCHEMBL5006620 | 0.86 | PLD1 (0.41) | OPRL1HSD11B1PLD1KCNH2OPRM1 | |
| SCHEMBL4437940 | 0.85 | OPRL1 (0.45) | OPRL1HSD11B1PLD1KCNH2OPRM1 | |
| SCHEMBL4435630 | 0.84 | PLD1 (0.36) | OPRL1HSD11B1PLD1KCNH2OPRM1 | |
| SCHEMBL4432833 | 0.84 | OPRL1 (0.46) | OPRL1HSD11B1PLD1KCNH2OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080287479-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | PFIZER INC | 2008-11-20 | — | — | US | claimed |
| US-20080287479-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | PFIZER INC | 2008-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080287479-A1 | INHIBITORS OF SERINE PALMITOYLTRANSFERASE | SPTLC1, SPTLC2, CPT1A | OPRL1 2087/4885HSD11B1 201/4885PLD1 351/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.