Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | MYC | P01106 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3163523 | 0.84 | ALDH1A1 (0.54) | SMN1; SMN2MAPTHSD17B10NPC1RAB9A | |
| SCHEMBL3272823 | 0.80 | ALDH1A1 (0.45) | CASP3SMN1; SMN2MAPTHSD17B10NPC1 | |
| SCHEMBL4996724 | 0.77 | NPC1 (0.47) | SMN1; SMN2MAPTHSD17B10NPC1RAB9A | |
| SCHEMBL1478175 | 0.74 | TAAR1 (0.61) | CASP3SMN1; SMN2MAPTHSD17B10NPC1 | |
| SCHEMBL1219262 | 0.74 | KDM4E (0.62) | CASP3SMN1; SMN2MAPTHSD17B10NPC1 | |
| SCHEMBL4140166 | 0.73 | ALDH1A1 (0.45) | SMN1; SMN2MAPTHSD17B10NPC1RAB9A | |
| SCHEMBL30562824 | 0.73 | PDE10A (0.46) | SMN1; SMN2MAPTHSD17B10NPC1RAB9A | |
| SCHEMBL3533444 | 0.73 | PDE10A (0.46) | SMN1; SMN2MAPTHSD17B10NPC1RAB9A | |
| SCHEMBL3063935 | 0.73 | MAPT (0.53) | SMN1; SMN2MAPTHSD17B10NPC1RAB9A | |
| SCHEMBL2133755 | 0.71 | CYP11B2 (0.51) | SMN1; SMN2MAPTNPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194574-A1 | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases | AXXIMA PHARMACEUTICALS AG (DE) | 2008-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194574-A1 | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases | PRNP, PSEN1, PPP5C | CASP3 402/4885SMN1; SMN2 896/4885MAPT 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.