Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.45 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.41 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.41 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4997510 | 0.86 | MAPT (0.60) | MAPTGAATHRBHTR7NPC1 | |
| SCHEMBL4992856 | 0.84 | TP53 (0.50) | MAPTGAAMAP4K1HTR7SMN1; SMN2 | |
| SCHEMBL4997110 | 0.84 | MAP4K1 (0.48) | MAPTGAAMAP4K1HTR7SMN1; SMN2 | |
| SCHEMBL4994280 | 0.83 | MAP4K1 (0.45) | MAPTGAAMAP4K1HTR7SMN1; SMN2 | |
| SCHEMBL4996131 | 0.83 | FYN (0.43) | MAPTGAAMAP4K1SMN1; SMN2NPC1 | |
| SCHEMBL5000876 | 0.83 | ALDH1A1 (0.43) | MAPTGAAMAP4K1THRBHTR7 | |
| SCHEMBL5000621 | 0.83 | MAP4K1 (0.43) | MAPTGAAMAP4K1THRBHTR7 | |
| SCHEMBL4995030 | 0.82 | MET (0.51) | MAPTGAAMAP4K1HTR7SMN1; SMN2 | |
| SCHEMBL4994661 | 0.81 | ACVR1 (0.42) | MAPTGAAMAP4K1HTR7TGFBR1 | |
| SCHEMBL5000886 | 0.81 | MAPT (0.46) | MAPTGAATHRBSMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194574-A1 | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases | AXXIMA PHARMACEUTICALS AG (DE) | 2008-08-14 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194574-A1 | Pyrazine Derivatives As Effective Compounds Against Infectious Diseases | PRNP, PSEN1, PPP5C | MAPT 5/4885GAA 2137/4885MAP4K1 980/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.