SCHEMBL50031

SCHEMBL50031

CC(=O)Nc1c[c]ccc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 2/20 0.57
NAPRT Q6XQN6 1/20 0.57
KMT2A Q03164 3/20 0.50
RAB9A P51151 3/20 0.50
MAPT P10636 2/20 0.50
POLB P06746 2/20 0.50
NPC1 O15118 1/20 0.50
TAAR1 Q96RJ0 1/20 0.50
ALDH1A1 P00352 6/20 0.48
CYP1A2 P05177 1/20 0.48
GAA P10253 1/20 0.47
L3MBTL1 Q9Y468 3/20 0.47
SMN1; SMN2 Q16637 3/20 0.47
HTT P42858 1/20 0.47
MEN1 O00255 2/20 0.45
TDP1 Q9NUW8 1/20 0.45
CA12 O43570 1/20 0.45
BRD4 O60885 1/20 0.45
NR1I2 O75469 1/20 0.45
CA1 P00915 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6990986 0.85 NPC1 (0.44) HSD17B10NAPRTKMT2ARAB9AMAPT
SCHEMBL3911427 0.82 TDP1 (0.54) HSD17B10NAPRTKMT2ARAB9APOLB
SCHEMBL2531539 0.82 EPHX2 (0.41) HSD17B10NAPRTKMT2ARAB9AMAPT
SCHEMBL731180 0.81 NQO2 (0.54) HSD17B10KMT2ARAB9AMAPTPOLB
SCHEMBL746119 0.81 ALDH1A1 (0.47) HSD17B10NAPRTKMT2ARAB9AMAPT
SCHEMBL359677 0.81 SMN1; SMN2 (0.48) KMT2ARAB9AMAPTPOLBNPC1
SCHEMBL1419142 0.81 TSHR (0.50) TSHR
SCHEMBL2225814 0.80 SMN1; SMN2 (0.63) HSD17B10NAPRTKMT2ARAB9AMAPT
SCHEMBL789578 0.80 GAA (0.50) HSD17B10KMT2AMAPTNPC1ALDH1A1
SCHEMBL6973539 0.80 TAS2R38 (0.57) HSD17B10NAPRTKMT2ARAB9AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 3478 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117858910-A Copolymer, piezoelectric material, piezoelectric film, and piezoelectric element TDK株式会社 2024-04-09 CN claimed
US-20230339904-A1 ISOINDOLINONES, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS BIOTHERYX, INC. 2023-10-26 US claimed
CN-113816889-B 4-sulfimide-1H-pyrrole Mcl-1 inhibitor and anti-tumor medical application thereof 中国药科大学 2023-08-22 CN claimed
US-20230201178-A1 PROLYL HYDROXYLASE INHIBITORS AND METHODS OF USE KREOS CAPITAL VII (UK) LIMITED (GB) 2023-06-29 US claimed
CN-116234546-A GPX4 inhibitors, pharmaceutical compositions thereof and their use in the treatment of GPX4 mediated diseases 嘉兴优博生物技术有限公司 2023-06-06 CN claimed
CN-113135922-B Azepane [4,3,2-cd ] isoindol-2-one derivatives and application thereof 中国药科大学 2023-05-30 CN claimed
US-20230148214-A1 INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS ESCAPE Bio, Inc. 2023-05-11 US claimed
WO-2023032614-A1 COPOLYMER, PIEZOELECTRIC MATERIAL, PIEZOELECTRIC FILM, AND PIEZOELECTRIC ELEMENT TDK株式会社 2023-03-09 WO claimed
CN-113816889-A 4-sulfimide-1H-pyrrole Mcl-1 inhibitor and anti-tumor medical application thereof 中国药科大学 2021-12-21 CN claimed
EP-3523292-B1 HETEROARYL COMPOUNDS AND THEIR USE AS MER INHIBITORS DONG A SOCIO HOLDINGS CO LTD (KR) 2021-12-15 EP claimed
WO-1993023038-A1 17-AMINO SUBSTITUTED 4-AZASTEROID 5α-REDUCTASE INHIBITORS MERCK & CO., INC. (US) 1993-11-25 WO claimed
EP-0568092-A2 Silver halide emulsion sensitized with a heavy metal compound and a thiourea compound EASTMAN KODAK COMPANY (a New Jersey corporation) (US) 1993-11-03 EP claimed
US-4933442-A 1-(acetylaminophenyl)-2-aminopropanone derivatives and central nervous system antidepressant compositions LABORATOIRE L. LAFON (FR) 1990-06-12 US claimed
US-4877812-A 1-(acetylaminophenyl)-2-aminopropanone derivatives and antidepressant compositions thereof LABORATOIRE L. LAFON (FR) 1989-10-31 US claimed
EP-0138714-B1 1-(ACETYLAMINOPHENYL)-2-AMINO-PROPANONE DERIVATIVES, THEIR THERAPEUTICAL USE AND PROCESS FOR THEIR PREPARATION LABORATOIRE L. LAFON Société anonyme dite: (FR) 1987-05-20 EP claimed
US-4529804-A Naphthostyril Ni or Cu complexes, a process for their preparation, and high molecular weight organic material pigmented with these metal complexes CIBA-GEIGY CORPORATION (US) 1985-07-16 US claimed
EP-0138714-A2 1-(Acetylaminophenyl)-2-amino-propanone derivatives, their therapeutical use and process for their preparation LABORATOIRE L. LAFON Société anonyme dite: (FR) 1985-04-24 EP claimed
EP-0034349-B1 NOVEL PYRIDINECARBOXAMIDE DERIVATIVES, A PROCESS FOR THE PREPARATION THEREOF, THE USE OF SAID DERIVATIVES AND A PHARMACEUTICAL COMPOSITION CONTAINING SAME Tanabe Seiyaku Co., Ltd. (JP) 1983-12-14 EP claimed
EP-0034349-A2 Novel pyridinecarboxamide derivatives, a process for the preparation thereof, the use of said derivatives and a pharmaceutical composition containing same Tanabe Seiyaku Co., Ltd. (JP) 1981-08-26 EP claimed
US-4032652-A SUBSTITUTED 2H-PYRAN-2,6(3H)-DIONE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS COMPRISING SUCH DERIVATIVES AND METHODS OF INHIBITING THE ANTIGEN-ANTIBODY REACTION SMITHKLINE CORPORATION (US) 1977-06-28 US claimed