Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.78 |
| ▸ | TP53 | P04637 | 1/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | HRH1 | P35367 | 10/20 | 0.64 |
| ▸ | DRD1 | P21728 | 6/20 | 0.59 |
| ▸ | DRD4 | P21917 | 5/20 | 0.59 |
| ▸ | DRD5 | P21918 | 5/20 | 0.59 |
| ▸ | DRD2 | P14416 | 4/20 | 0.59 |
| ▸ | DRD3 | P35462 | 4/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11631075 | 0.98 | HPGD (0.81) | HPGDSMN1; SMN2TP53CYP1A2CYP3A4 | |
| SCHEMBL11033196 | 0.95 | HPGD (0.81) | HPGDSMN1; SMN2TP53CYP1A2CYP3A4 | |
| SCHEMBL11031853 | 0.89 | HPGD (0.96) | HPGDSMN1; SMN2TP53CYP1A2CYP3A4 | |
| SCHEMBL5004402 | 0.84 | HRH1 (0.70) | HPGDSMN1; SMN2TP53CYP1A2CYP3A4 | |
| SCHEMBL9236565 | 0.83 | TP53 (0.67) | HPGDSMN1; SMN2TP53CYP1A2CYP3A4 | |
| SCHEMBL28360925 | 0.81 | TP53 (0.69) | HPGDSMN1; SMN2TP53CYP1A2CYP3A4 | |
| SCHEMBL11627611 | 0.81 | TP53 (0.65) | HPGDSMN1; SMN2TP53CYP1A2CYP3A4 | |
| SCHEMBL5004014 | 0.81 | HRH1 (0.66) | HPGDSMN1; SMN2TP53CYP1A2CYP3A4 | |
| SCHEMBL5146718 | 0.81 | HRH1 (0.71) | HPGDSMN1; SMN2TP53CYP1A2CYP3A4 | |
| SCHEMBL5249495 | 0.81 | HRH1 (0.66) | HPGDSMN1; SMN2TP53CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0684224-A1 | A process for the preparation of 2-(4-N-methylaminobutoxy)diphenylmethane | PROCOS S.p.A. (IT) | 1995-11-29 | — | — | EP | claimed |
| JP-7330694-A | — | — | None | — | — | JP | disclosed |
| EP-1697303-A4 | CATALYTIC HYDROGENATION OF NITRILES TO PRODUCE CAPSAICINOID DERIVATIVES AND AMINE COMPOUNDS, AND METHODS FOR PURIFIYING AND OBTAINING THE POLYMORPHS THEREOF | STIEFEL LABORATORIES (US) | 2007-07-04 | — | — | EP | disclosed |
| EP-1697303-A1 | CATALYTIC HYDROGENATION OF NITRILES TO PRODUCE CAPSAICINOID DERIVATIVES AND AMINE COMPOUNDS, AND METHODS FOR PURIFIYING AND OBTAINING THE POLYMORPHS THEREOF | STIEFEL LABORATORIES, INC. (US) | 2006-09-06 | — | — | EP | disclosed |
| US-20060047171-A1 | Catalytic hydrogenation of nitriles to produce capsaicinoid derivatives and amine compounds, and methods for purifying and obtaining the polymorphs thereof | STIEFEL LABORATORIES, INC. | 2006-03-02 | — | — | US | disclosed |
| WO-2005068414-A1 | CATALYTIC HYDROGENATION OF NITRILES TO PRODUCE CAPSAICINOID DERIVATIVES AND AMINE COMPOUNDS, AND METHODS FOR PURIFIYING AND OBTAINING THE POLYMORPHS THEREOF | STIEFEL LABORATORIES, INC. (US) | 2005-07-28 | — | — | WO | disclosed |
| JP-H07330694-A | PROCESS FOR PRODUCING 2-(4-N-METHYLAMINO-BUTOXY) DIPHENYLMETHANE | PROCOS SPA | 1995-12-19 | — | — | JP | disclosed |
| EP-0684224-A1 | A process for the preparation of 2-(4-N-methylaminobutoxy)diphenylmethane | PROCOS S.p.A. (IT) | 1995-11-29 | — | — | EP | disclosed |
| EP-0103897-B1 | PHARMACEUTICAL COMPOSITION USEFUL FOR IMPROVEMENT AND/OR TREATMENT OF MENTAL SYMPTOMS CAUSED BY ORGANIC DISORDER IN BRAIN | Eisai Co., Ltd. (JP) | 1987-02-04 | — | — | EP | disclosed |
| US-4576966-A | (METHYLAMINOBUTOXY) DIPHENYLMETHANE | EISAI CO., LTD. (JP) | 1986-03-18 | — | — | US | disclosed |
| US-4507322-A | ADMINISTERING 2,4-METHYLAMINOBUTOXYDIPHENYLMETHANE | EISAI CO., LTD. (JP) | 1985-03-26 | — | — | US | disclosed |
| EP-0103897-A1 | Pharmaceutical composition useful for improvement and/or treatment of mental symptoms caused by organic disorder in brain | Eisai Co., Ltd. (JP) | 1984-03-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060047171-A1 | Catalytic hydrogenation of nitriles to produce capsaicinoid derivatives and amine compounds, and methods for purifying and obtaining the polymorphs thereof | HPD, HNMT, PRPH | HPGD 9/4885SMN1; SMN2 1017/4885TP53 3538/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.