Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.37 |
| ▸ | SLC13A5 | Q86YT5 | 5/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | OXTR | P30559 | 1/20 | 0.36 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | BCL2 | P10415 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5007313 | 0.87 | SMN1; SMN2 (0.42) | RARBSLC13A5NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5006829 | 0.86 | NPC1 (0.42) | RARBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5005989 | 0.73 | SMN1; SMN2 (0.42) | RARBPDE4DNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2395007 | 0.72 | MAPT (0.48) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1748179 | 0.72 | NPC1 (0.43) | RARBPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL585945 | 0.71 | ALDH1A1 (0.47) | SLC13A5NPC1RAB9ASMN1; SMN2HIF1A | |
| SCHEMBL18085386 | 0.71 | ALDH1A1 (0.47) | SLC13A5NPC1RAB9ASMN1; SMN2HIF1A | |
| SCHEMBL5006802 | 0.71 | HDAC3 (0.44) | NPC1RAB9A | |
| SCHEMBL12313907 | 0.71 | RARB (0.40) | RARBPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL12428576 | 0.69 | AR (0.44) | RARBNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423156-B2 | Preparation and use of aryl alkyl acid derivatives for the treatment of obesity | BAYER PHARMACEUTICALS CORPORATION (US) | 2008-09-09 | — | — | US | disclosed |