Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 8/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 6/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 6/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL499079 | 0.76 | REN (0.48) | HPGDCYP1A2CYP2C9CYP2C19MEN1 | |
| SCHEMBL499080 | 0.76 | REN (0.48) | HPGDCYP1A2CYP2C9CYP2C19MEN1 | |
| SCHEMBL499101 | 0.76 | REN (0.48) | HPGDCYP1A2CYP2C9CYP2C19MEN1 | |
| SCHEMBL499046 | 0.70 | SLC6A2 (0.52) | SLC6A4SLC6A2ADRB3ADRB1ADRB2 | |
| SCHEMBL8229887 | 0.67 | ADRB2 (0.42) | SLC6A4SLC6A2ADRB3ADRB1ADRB2 | |
| SCHEMBL17330350 | 0.67 | PNMT (0.56) | HPGDMEN1KMT2A | |
| SCHEMBL16403709 | 0.67 | NPC1 (0.51) | HPGDADRB3ADRB1ADRB2ALDH1A1 | |
| SCHEMBL16403707 | 0.67 | NPC1 (0.51) | HPGDADRB3ADRB1ADRB2ALDH1A1 | |
| SCHEMBL4596498 | 0.66 | MAPK1 (0.51) | MEN1KMT2A | |
| SCHEMBL3446408 | 0.66 | MAPK1 (0.51) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8106221-B2 | Renin inhibitors | VITAE PHARMACEUTICALS, INC. (US) | 2012-01-31 | — | — | US | disclosed |
| US-20100144825-A1 | Renin Inhibitors | VITAE PHARMACEUTICALS, INC. | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144825-A1 | Renin Inhibitors | ACE, REN, DNPEP | HPGD 579/4885SLC6A4 603/4885SLC6A2 344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.