Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.39 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.39 |
| ▸ | ITGAL | P20701 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL360635 | 0.89 | CXCL8 (0.45) | GAAKMT2ACXCL8ALDH1A1ABCB11 | |
| SCHEMBL7576115 | 0.89 | KMT2A (0.46) | GAAKMT2AALDH1A1MAPK1LMNA | |
| SCHEMBL11271011 | 0.87 | CXCL8 (0.44) | GAAKMT2ACXCL8ALDH1A1ABCB11 | |
| SCHEMBL6809250 | 0.87 | CXCL8 (0.44) | GAAKMT2ACXCL8ALDH1A1ABCB11 | |
| SCHEMBL3132378 | 0.86 | PTGS2 (0.48) | GAAKMT2AABCB11PTGS1PTGS2 | |
| SCHEMBL27660511 | 0.85 | PTGS2 (0.47) | GAAKMT2AABCB11PTGS1PTGS2 | |
| SCHEMBL28355542 | 0.83 | FPR2 (0.42) | HTTKMT2ACXCL8ALDH1A1ABCB11 | |
| SCHEMBL27577407 | 0.80 | HTT (0.44) | GAAHTTATMNPSR1TDP1 | |
| SCHEMBL27562422 | 0.78 | MEN1 (0.41) | GAAKMT2ACXCL8ALDH1A1ABCB11 | |
| Trolamine SCHEMBL10993885 | 0.77 | CXCL8 (0.37) | GAAHTTNPSR1KMT2ACXCL8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-100406008-C | Pharmaceutical composition comprising lumiracoxib | NOVARTIS AG (CH) | 2008-07-30 | — | — | CN | claimed |
| CN-1455691-A | Pharmaceutical composition | NOVARTIS AG (CH) | 2003-11-12 | — | — | CN | claimed |
| CN-104000818-B | tuberous sclerosis treatment | 诺瓦提斯公司 | 2017-11-21 | — | — | CN | disclosed |
| EP-3171876-A1 | COMBINATION THERAPY | Novartis AG (CH) | 2017-05-31 | — | — | EP | disclosed |
| WO-2016011956-A1 | COMBINATION THERAPY | NOVARTIS AG (CH) | 2016-01-28 | — | — | WO | disclosed |
| CN-100490797-C | Pharmaceutical composition | NOVARTIS AG (CH) | 2009-05-27 | — | — | CN | disclosed |
| US-20080287543-A1 | Pharmaceutical composition comprising 5-methyl-2 (2'-chloro-6'-fluoroanillino) phen ylacetic acid | DANNENFELSER ROSE-MARIE | 2008-11-20 | — | — | US | disclosed |
| CN-1283240-C | Pharmaceutical use of COX-2 inhibitors in angiogenesis-mediated ocular disorders | NOVARTIS AG (CH) | 2006-11-08 | — | — | CN | disclosed |
| CN-1726030-A | Combinations of valsartan with cox-2 inhibitors | NOVARTIS AG (CH) | 2006-01-25 | — | — | CN | disclosed |
| CN-1620288-A | Pharmaceutical use of COX-2 inhibitors in angiogenesis-mediated ocular disorders | NOVARTIS AG (CH) | 2005-05-25 | — | — | CN | disclosed |
| CN-1455691-A | Pharmaceutical composition | NOVARTIS AG (CH) | 2003-11-12 | — | — | CN | disclosed |
| EP-1331972-A2 | PHARMACEUTICAL COMPOSITIONS | Novartis AG (CH) | 2003-08-06 | — | — | EP | disclosed |
| EP-1242069-A2 | ALBUMIN-BINDING COMPOUNDS THAT PREVENT NONENZYMATIC GLYCATION AND THAT MAY BE USED FOR TREATMENT OF GLYCATION-RELATED PATHOLOGIES | EXOCELL, INC. (US) | 2002-09-25 | — | — | EP | disclosed |
| WO-2002020090-A2 | PHARMACEUTICAL COMPOSITIONS | NOVARTIS AG (CH) | 2002-03-14 | — | — | WO | disclosed |
| WO-2001003684-A2 | ALBUMIN-BINDING COMPOUNDS THAT PREVENT NONENZYMATIC GLYCATION AND THAT MAY BE USED FOR TREATMENT OF GLYCATION-RELATED PATHOLOGIES | EXOCELL, INC. (US) | 2001-01-18 | — | — | WO | disclosed |