Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7976728 | 0.79 | POLB (0.62) | HPGDALDH1A1KDM4ERAB9APOLB | |
| SCHEMBL5008590 | 0.76 | POLB (0.56) | HPGDALDH1A1KDM4ERAB9APOLB | |
| SCHEMBL11013240 | 0.75 | HPGD (0.75) | HPGDALDH1A1KDM4ERAB9APOLB | |
| SCHEMBL14067517 | 0.74 | POLB (0.69) | HPGDALDH1A1KDM4ERAB9APOLB | |
| SCHEMBL4808220 | 0.73 | RAB9A (0.67) | HPGDALDH1A1RAB9APOLBHTT | |
| SCHEMBL4651767 | 0.70 | RAB9A (0.71) | HPGDALDH1A1RAB9APOLBHTT | |
| SCHEMBL8265142 | 0.69 | HPGD (0.73) | HPGDALDH1A1KDM4ERAB9APOLB | |
| SCHEMBL13923633 | 0.69 | RAB9A (0.65) | HPGDALDH1A1KDM4ERAB9APOLB | |
| SCHEMBL708029 | 0.68 | POLB (0.77) | HPGDALDH1A1RAB9APOLBHTT | |
| SCHEMBL14067814 | 0.68 | POLB (0.60) | HPGDALDH1A1KDM4ERAB9APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968946-A1 | IMIDAZOLES AS GABA-B RECEPTOR MODULATORS | AstraZeneca AB (SE) | 2008-09-17 | — | — | EP | claimed |
| WO-2007073299-A1 | IMIDAZOLES AS GABA-B RECEPTOR MODULATORS | ASTRAZENECA AB (SE) | 2007-06-28 | — | — | WO | claimed |