Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.73 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL708029 | 0.76 | POLB (0.77) | HPGDPOLBMEN1KMT2AGAA | |
| SCHEMBL11013240 | 0.75 | HPGD (0.75) | HPGDPOLBMEN1KMT2AGAA | |
| SCHEMBL7339035 | 0.75 | HPGD (0.71) | HPGDPOLBMEN1KMT2AGAA | |
| SCHEMBL14923269 | 0.74 | HPGD (0.68) | HPGDPOLBMEN1KMT2AGAA | |
| SCHEMBL13722291 | 0.72 | NPY5R (0.49) | CYP3A4CYP2D6ALDH1A1KDM4E | |
| SCHEMBL7600283 | 0.71 | HPGD (0.63) | HPGDPOLBMEN1KMT2AGAA | |
| SCHEMBL7523294 | 0.71 | HPGD (0.63) | HPGDPOLBMEN1KMT2AGAA | |
| SCHEMBL8178243 | 0.69 | HPGD (0.60) | HPGDPOLBMEN1KMT2AGAA | |
| SCHEMBL13973078 | 0.69 | HPGD (0.61) | HPGDPOLBMEN1KMT2AGAA | |
| SCHEMBL5007799 | 0.69 | HPGD (0.64) | HPGDPOLBMEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838304-B1 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS | SCHERING CORP (US) | 2009-08-19 | — | — | EP | disclosed |
| WO-2006065277-A2 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS | SCHERING CORPORATION (US) | 2006-06-22 | — | — | WO | disclosed |