Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.40 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.40 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.40 |
| ▸ | FPR2 | P25090 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21654192 | 0.85 | CES2 (0.46) | CES2CES1LMNAALDH1A1CA1 | |
| SCHEMBL5006817 | 0.77 | LMNA (0.40) | LMNAALDH1A1CA1CA2KMT2A | |
| SCHEMBL727222 | 0.76 | CES2 (0.54) | CES2CES1LMNAALDH1A1CA1 | |
| SCHEMBL20565073 | 0.76 | CYP1A2 (0.44) | LMNAALDH1A1KMT2AMEN1FPR2 | |
| SCHEMBL5889317 | 0.75 | CES2 (0.48) | CES2CES1LMNAALDH1A1CA1 | |
| SCHEMBL23544612 | 0.74 | CES2 (0.52) | CES2CES1LMNAALDH1A1CA1 | |
| SCHEMBL20703078 | 0.74 | CES2 (0.52) | CES2CES1LMNAALDH1A1CA1 | |
| SCHEMBL634337 | 0.74 | CES2 (0.52) | CES2CES1LMNAALDH1A1CA1 | |
| SCHEMBL5011661 | 0.74 | CES2 (0.52) | CES2CES1LMNAALDH1A1CA1 | |
| SCHEMBL5783383 | 0.74 | CES2 (0.52) | CES2CES1LMNAALDH1A1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423156-B2 | Preparation and use of aryl alkyl acid derivatives for the treatment of obesity | BAYER PHARMACEUTICALS CORPORATION (US) | 2008-09-09 | — | — | US | disclosed |