Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | MMP7 | P09237 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 3/20 | 0.37 |
| ▸ | RXRB | P28702 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5006804 | 0.82 | ALDH1A1 (0.47) | LMNAHTTSMN1; SMN2ALDH1A1CYP3A4 | |
| SCHEMBL5005996 | 0.81 | HDAC1 (0.40) | LMNAHTTSMN1; SMN2ALDH1A1RXRA | |
| SCHEMBL5007308 | 0.79 | ALDH1A1 (0.51) | LMNAHTTALDH1A1CYP3A4KDM4E | |
| SCHEMBL5009253 | 0.77 | CES2 (0.43) | LMNASMN1; SMN2ALDH1A1CA1CA2 | |
| SCHEMBL5005972 | 0.77 | TAAR1 (0.37) | LMNAHTTSMN1; SMN2ALDH1A1RXRA | |
| SCHEMBL2449415 | 0.72 | KDM4E (0.52) | LMNASMN1; SMN2ALDH1A1CYP3A4CYP1A2 | |
| SCHEMBL1748034 | 0.71 | SMN1; SMN2 (0.44) | LMNASMN1; SMN2ALDH1A1CA12CA1 | |
| Benzidine SCHEMBL15658492 | 0.70 | MMP1 (0.51) | ALDH1A1MMP1MMP2MMP3MMP7 | |
| SCHEMBL31533508 | 0.70 | PARP10 (0.45) | LMNASMN1; SMN2ALDH1A1CYP3A4CYP1A2 | |
| SCHEMBL9364482 | 0.70 | LMNA (0.44) | LMNAHTTSMN1; SMN2ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423156-B2 | Preparation and use of aryl alkyl acid derivatives for the treatment of obesity | BAYER PHARMACEUTICALS CORPORATION (US) | 2008-09-09 | — | — | US | disclosed |