Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | NQO2 | P16083 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5011043 | 0.84 | MMP2 (0.34) | MMP8MMP2MMP9AKR1B1MAPT | |
| SCHEMBL1748194 | 0.75 | MMP8 (0.44) | MMP8POLBMAPK1GSK3BMMP2 | |
| SCHEMBL5005961 | 0.73 | MMP8 (0.44) | MMP8POLBMAPK1GSK3BMMP2 | |
| SCHEMBL1748236 | 0.71 | MMP8 (0.47) | MMP8POLBMAPK1GSK3BMMP2 | |
| SCHEMBL16690227 | 0.66 | GSK3B (0.61) | MMP8POLBMAPK1GSK3BMAPT | |
| Water SCHEMBL29199054 | 0.65 | GSK3B (0.59) | MMP8POLBMAPK1GSK3BMAPT | |
| SCHEMBL11756878 | 0.64 | FFAR1 (0.64) | POLBMAPK1GSK3BMAPTCYP1A2 | |
| SCHEMBL17973393 | 0.64 | MAPK1 (0.58) | MMP8POLBMAPK1GSK3BMAPT | |
| SCHEMBL7369237 | 0.63 | GSK3B (0.89) | POLBMAPK1GSK3BTDP1HSD11B1 | |
| SCHEMBL7208394 | 0.63 | GSK3B (0.65) | MMP8POLBMAPK1GSK3BMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423156-B2 | Preparation and use of aryl alkyl acid derivatives for the treatment of obesity | BAYER PHARMACEUTICALS CORPORATION (US) | 2008-09-09 | — | — | US | disclosed |