Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.56 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.46 |
| ▸ | RORC | P51449 | 12/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5011613 | 0.90 | APP (0.56) | APPAKR1C3AKR1C2RORCCYP3A4 | |
| SCHEMBL4494820 | 0.77 | APP (0.56) | APPAKR1C3AKR1C2CYP3A4CYP2C9 | |
| SCHEMBL4498505 | 0.75 | APP (0.54) | APPAKR1C3AKR1C2CYP3A4CYP2C9 | |
| SCHEMBL4501897 | 0.74 | APP (0.53) | APPAKR1C3AKR1C2CYP3A4CYP2C9 | |
| SCHEMBL5009745 | 0.74 | APP (0.55) | APPAKR1C3AKR1C2CYP3A4CYP2C9 | |
| SCHEMBL5011544 | 0.69 | RORC (0.46) | APPRORCPSEN1PSEN2APH1B | |
| SCHEMBL8755138 | 0.69 | APP (0.78) | APPAKR1C3AKR1C2CYP3A4CYP2C9 | |
| SCHEMBL3938352 | 0.69 | APP (0.78) | APPAKR1C3AKR1C2CYP3A4CYP2C9 | |
| SCHEMBL29130916 | 0.68 | MAPT (0.47) | APPAKR1C3AKR1C2CYP3A4CYP2C9 | |
| SCHEMBL24031016 | 0.67 | RORC (0.51) | APPAKR1C3AKR1C2RORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893562-A1 | REVERSIBLE INHIBITORS OF MONOAMINE OXIDASE A AND B | Merck Frosst Canada Ltd. (CA) | 2008-03-05 | — | — | EP | claimed |
| WO-2006133559-A1 | REVERSIBLE INHIBITORS OF MONOAMINE OXIDASE A AND B | MERCK FROSST CANADA LTD. (CA) | 2006-12-21 | — | — | WO | claimed |
| EP-1893562-A1 | REVERSIBLE INHIBITORS OF MONOAMINE OXIDASE A AND B | Merck Frosst Canada Ltd. (CA) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006133559-A1 | REVERSIBLE INHIBITORS OF MONOAMINE OXIDASE A AND B | MERCK FROSST CANADA LTD. (CA) | 2006-12-21 | — | — | WO | disclosed |