Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.63 |
| ▸ | CYP4Z1 | Q86W10 | 3/20 | 0.56 |
| ▸ | CYP4F11 | Q9HBI6 | 1/20 | 0.56 |
| ▸ | CYP4F12 | Q9HCS2 | 1/20 | 0.56 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.55 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.53 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | F10 | P00742 | 1/20 | 0.47 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14755726 | 0.95 | MAPK1 (0.58) | MAPK1TDP1GAANPSR1CYP4Z1 | |
| SCHEMBL7806829 | 0.86 | ALOX5 (0.58) | MAPK1TDP1GAANPSR1CYP4Z1 | |
| SCHEMBL803447 | 0.86 | HSD17B10 (0.63) | MAPK1TDP1GAANPSR1CYP4Z1 | |
| SCHEMBL7175928 | 0.84 | MAPK1 (0.56) | MAPK1TDP1GAANPSR1CYP4Z1 | |
| SCHEMBL1467579 | 0.84 | CYP4F2 (0.58) | MAPK1TDP1GAANPSR1CYP4Z1 | |
| SCHEMBL10463270 | 0.84 | CYP1A2 (0.65) | MAPK1TDP1GAANPSR1CYP4Z1 | |
| SCHEMBL10463522 | 0.84 | CYP1A2 (0.59) | MAPK1TDP1GAANPSR1CYP4Z1 | |
| SCHEMBL10289874 | 0.83 | CYP4F2 (0.62) | MAPK1TDP1GAANPSR1CYP4Z1 | |
| SCHEMBL765000 | 0.83 | CYP4F2 (0.62) | MAPK1TDP1GAANPSR1CYP4Z1 | |
| SCHEMBL765847 | 0.83 | CYP4F2 (0.62) | MAPK1TDP1GAANPSR1CYP4Z1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1884513-A1 | PYRAZOLE COMPOUND AND THERAPEUTIC AGENT FOR DIABETES COMPRISING THE SAME | Japan Tobacco, Inc. (JP) | 2008-02-06 | — | — | EP | claimed |
| US-20070032529-A1 | Pyrazole compounds and their use as antidiabetes agents | JAPAN TOBACCO INC. (JP) | 2007-02-08 | — | — | US | claimed |
| EP-1884513-A1 | PYRAZOLE COMPOUND AND THERAPEUTIC AGENT FOR DIABETES COMPRISING THE SAME | Japan Tobacco, Inc. (JP) | 2008-02-06 | — | — | EP | disclosed |
| US-20070032529-A1 | Pyrazole compounds and their use as antidiabetes agents | JAPAN TOBACCO INC. (JP) | 2007-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070032529-A1 | Pyrazole compounds and their use as antidiabetes agents | PYGL, GYS2, AGL | MAPK1 1165/4885TDP1 2797/4885GAA 53/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.