Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BBOX1 | O75936 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 5/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | APOBEC3A | P31941 | 2/20 | 0.34 |
| ▸ | APOBEC3G | Q9HC16 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GMNN | O75496 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5009177 | 0.91 | BBOX1 (0.47) | BBOX1LMNATSHRPMP22CYP3A4 | |
| SCHEMBL2396073 | 0.89 | BBOX1 (0.46) | BBOX1LMNATSHRPMP22CYP3A4 | |
| Trifluoromethanesulfonic Acid SCHEMBL5012756 | 0.87 | BBOX1 (0.39) | BBOX1LMNATSHRPMP22CYP3A4 | |
| SCHEMBL5011415 | 0.85 | BBOX1 (0.46) | BBOX1LMNATSHRPMP22CYP3A4 | |
| SCHEMBL24072018 | 0.84 | BBOX1 (0.44) | BBOX1LMNATSHRPMP22CYP3A4 | |
| Trifluoromethanesulfonic Acid SCHEMBL5010382 | 0.82 | LMNA (0.38) | BBOX1LMNATSHRPMP22CYP3A4 | |
| SCHEMBL24072021 | 0.77 | KDM4E (0.42) | BBOX1LMNATSHRPMP22CYP3A4 | |
| SCHEMBL8108400 | 0.75 | HPGD (0.41) | BBOX1LMNATSHRPMP22SMN1; SMN2 | |
| SCHEMBL19750030 | 0.72 | BBOX1 (0.33) | BBOX1LMNATSHRPMP22CYP3A4 | |
| SCHEMBL1111598 | 0.72 | DNM1 (0.35) | BBOX1LMNATSHRPMP22CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080193853-A1 | Lithium Salts of Pyrroldinium Type Zwitterion and the Preparation Method of the Same | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2008-08-14 | — | — | US | disclosed |