Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | DPP4 | P27487 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | ANPEP | P15144 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30608945 | 0.90 | USP30 (0.43) | ALDH1A1SMN1; SMN2DPP4MAPK1DPP8 | |
| SCHEMBL30440955 | 0.83 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2DPP4MAPK1DPP8 | |
| SCHEMBL26136601 | 0.81 | SMN1; SMN2 (0.47) | ALDH1A1SMN1; SMN2DPP4MAPK1DPP8 | |
| SCHEMBL19028116 | 0.78 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2DPP4MAPK1DPP8 | |
| SCHEMBL29223963 | 0.77 | GPR119 (0.48) | ALDH1A1SMN1; SMN2KDM4ENPC1GAA | |
| SCHEMBL16759087 | 0.77 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2MAPK1KDM4ENPC1 | |
| SCHEMBL29616770 | 0.77 | CHRNB2 (0.45) | ALDH1A1SMN1; SMN2DPP4 | |
| SCHEMBL21460359 | 0.76 | SMN1; SMN2 (0.47) | SMN1; SMN2NPC1RAB9A | |
| SCHEMBL19028145 | 0.75 | NPC1 (0.42) | ALDH1A1SMN1; SMN2MAPK1KDM4ENPC1 | |
| SCHEMBL16759301 | 0.75 | SMN1; SMN2 (0.41) | ALDH1A1SMN1; SMN2MAPK1KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1987019-A1 | BENZOYL-PIPERIDINE DERIVATIVES AS 5HT2/D3 MODULATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-11-05 | — | — | EP | claimed |
| WO-2007093540-A1 | BENZOYL-PIPERIDINE DERIVATIVES AS 5HT2/D3 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-23 | — | — | WO | claimed |
| EP-1987019-A1 | BENZOYL-PIPERIDINE DERIVATIVES AS 5HT2/D3 MODULATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-11-05 | — | — | EP | disclosed |
| WO-2007093540-A1 | BENZOYL-PIPERIDINE DERIVATIVES AS 5HT2/D3 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-08-23 | — | — | WO | disclosed |