Sugi Predict

Sugi Predict / Compounds / SCHEMBL5010758

SCHEMBL5010758

SCHEMBL5010758

CCCN(Cc1cccnc1)C(=O)c1cc(NC(=O)c2cc(F)c(F)cc2Cl)[nH]n1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ F2 P00734 1/20 0.39
▸ ALDH1A1 P00352 6/20 0.39
▸ NPSR1 Q6W5P4 1/20 0.39
▸ HDAC3 O15379 2/20 0.38
▸ HDAC1 Q13547 2/20 0.38
▸ HDAC7 Q8WUI4 2/20 0.38
▸ HDAC2 Q92769 2/20 0.38
▸ HDAC10 Q969S8 2/20 0.38
▸ HDAC8 Q9BY41 2/20 0.38
▸ HDAC6 Q9UBN7 2/20 0.38
▸ HDAC9 Q9UKV0 2/20 0.38
▸ HDAC5 Q9UQL6 2/20 0.38
▸ HDAC4 P56524 1/20 0.38
▸ HDAC11 Q96DB2 1/20 0.38
▸ GAA P10253 2/20 0.38
▸ KDM4E B2RXH2 2/20 0.38
▸ MEN1 O00255 2/20 0.38
▸ KMT2A Q03164 2/20 0.38
▸ NAMPT P43490 1/20 0.38
▸ RORC P51449 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5010347 0.95 HTT (0.40) F2ALDH1A1NPSR1HDAC3HDAC1
SCHEMBL14587662 0.87 HDAC1 (0.40) ALDH1A1HDAC3HDAC1HDAC7HDAC2
SCHEMBL5010616 0.86 HDAC1 (0.45) ALDH1A1HDAC3HDAC1HDAC7HDAC2
SCHEMBL14587665 0.85 HTT (0.38) ALDH1A1HDAC3HDAC1HDAC7HDAC2
SCHEMBL14587661 0.85 HDAC1 (0.39) ALDH1A1HDAC3HDAC1HDAC7HDAC2
SCHEMBL14587656 0.84 NTRK1 (0.40) ALDH1A1HDAC3HDAC1HDAC7HDAC2
SCHEMBL5008526 0.84 PPARG (0.45) ALDH1A1HDAC3HDAC1HDAC7HDAC10
SCHEMBL5009786 0.83 USP2 (0.43) F2ALDH1A1KDM4EMEN1KMT2A
SCHEMBL5010768 0.83 ALDH1A1 (0.43) ALDH1A1HDAC1HDAC6MEN1KMT2A
SCHEMBL5008428 0.82 SMN1; SMN2 (0.42) ALDH1A1HDAC1HDAC6KDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1884513-A1 PYRAZOLE COMPOUND AND THERAPEUTIC AGENT FOR DIABETES COMPRISING THE SAME Japan Tobacco, Inc. (JP) 2008-02-06 — — EP claimed
US-20070032529-A1 Pyrazole compounds and their use as antidiabetes agents JAPAN TOBACCO INC. (JP) 2007-02-08 — — US claimed
EP-1884513-A1 PYRAZOLE COMPOUND AND THERAPEUTIC AGENT FOR DIABETES COMPRISING THE SAME Japan Tobacco, Inc. (JP) 2008-02-06 — — EP disclosed
US-20070032529-A1 Pyrazole compounds and their use as antidiabetes agents JAPAN TOBACCO INC. (JP) 2007-02-08 — — US disclosed
US-20070032529-A1 Pyrazole compounds and their use as antidiabetes agents JAPAN TOBACCO INC. (JP) 2007-02-08 — — US disclosed
US-20070032529-A1 Pyrazole compounds and their use as antidiabetes agents JAPAN TOBACCO INC. (JP) 2007-02-08 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070032529-A1 Pyrazole compounds and their use as antidiabetes agents PYGL, GYS2, AGL F2 3557/4885ALDH1A1 1278/4885NPSR1 3984/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.