Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | P4HTM | Q9NXG6 | 3/20 | 0.52 |
| ▸ | CCR1 | P32246 | 2/20 | 0.52 |
| ▸ | CCR5 | P51681 | 2/20 | 0.52 |
| ▸ | CCR8 | P51685 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | METAP1 | P53582 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | DOHH | Q9BU89 | 1/20 | 0.52 |
| ▸ | EDNRA | P25101 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8641370 | 0.85 | TDP2 (0.46) | KDM4ELMNAP4HTMCCR1CCR5 | |
| Dipyridyl SCHEMBL27903420 | 0.82 | KDM4E (0.70) | KDM4ELMNAP4HTMCCR1CCR5 | |
| SCHEMBL1205852 | 0.81 | EDNRA (0.52) | KDM4ELMNAP4HTMCCR1CCR5 | |
| SCHEMBL28898669 | 0.81 | EDNRA (0.49) | KDM4ELMNAP4HTMCCR1CCR5 | |
| SCHEMBL1667127 | 0.81 | EDNRA (0.49) | KDM4ELMNAP4HTMCCR1CCR5 | |
| SCHEMBL29967288 | 0.81 | EDNRA (0.49) | KDM4ELMNAP4HTMCCR1CCR5 | |
| SCHEMBL27751597 | 0.81 | EDNRA (0.47) | KDM4ELMNACYP1A2POLBBLM | |
| SCHEMBL27727298 | 0.81 | EDNRA (0.42) | KDM4EPOLBEDNRAALOX15ALDH1A1 | |
| SCHEMBL5691577 | 0.80 | KDM4E (0.47) | KDM4ELMNAP4HTMCCR1CCR5 | |
| SCHEMBL5314142 | 0.80 | KDM4E (0.50) | KDM4ELMNAP4HTMCCR1CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697362-B1 | CRF RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO | SB PHARMCO INC (PR) | 2008-03-05 | — | — | EP | disclosed |
| US-20070293508-A1 | Crf Receptor Antagonists and Methods Relating Thereto | SB PHARMCO PUERTO RICO INC AND NEUROCRINE BIOSCIENCES, INC. (US) | 2007-12-20 | — | — | US | disclosed |
| EP-1697362-A1 | CRF RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO | SB Pharmco Puerto Rico Inc. (PR) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005063749-A1 | CRF RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO | SB PHARMCO PUERTO RICO INC (GB) | 2005-07-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293508-A1 | Crf Receptor Antagonists and Methods Relating Thereto | CRHR1, CRHR2, SCTR | KDM4E 4530/4885LMNA 3846/4885P4HTM 632/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.