Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | PPARD | Q03181 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | CNR1 | P21554 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | TNKS | O95271 | 2/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL215399 | 0.86 | XDH (0.50) | XDHALDH1A1GABRA1GABRB2MAPT | |
| SCHEMBL14128652 | 0.79 | ALDH1A1 (0.42) | XDHALDH1A1GABRA1GABRB2MAPT | |
| SCHEMBL1245519 | 0.78 | XDH (0.44) | XDHALDH1A1GABRA1GABRB2MAPT | |
| SCHEMBL5830931 | 0.77 | XDH (0.45) | XDHALDH1A1GABRA1GABRB2MAPT | |
| SCHEMBL20391630 | 0.74 | XDH (0.41) | XDHALDH1A1GABRA1GABRB2MAPT | |
| SCHEMBL2161291 | 0.74 | XDH (0.41) | XDHALDH1A1GABRA1GABRB2MAPT | |
| SCHEMBL12802107 | 0.74 | ALDH1A1 (0.42) | XDHALDH1A1GABRA1GABRB2MAPT | |
| SCHEMBL15144566 | 0.74 | XDH (0.41) | XDHALDH1A1GABRA1GABRB2MAPT | |
| SCHEMBL20391245 | 0.74 | ALDH1A1 (0.42) | XDHALDH1A1GABRA1GABRB2MAPT | |
| SCHEMBL165601 | 0.74 | ALDH1A1 (0.52) | XDHALDH1A1GABRA1GABRB2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080214660-A1 | Compounds and Methods for the Inhibition of the Expression of VCAM-1 | CRABTREE ACQUISITION CO, LLC | 2008-09-04 | — | — | US | disclosed |
| US-7375252-B2 | Compounds and method for the inhibition of the expression of VCAM-1 | ATHEROGENICS, INC. (US) | 2008-05-20 | — | — | US | disclosed |
| US-7189870-B2 | Compounds and methods for the inhibition of the expression of VCAM-1 | ATHEROGENIC, INC. (US) | 2007-03-13 | — | — | US | disclosed |
| EP-1726582-A2 | Compounds and methods for the inhibition of the expression of vcam-1 | Atherogenics, Inc. (US) | 2006-11-29 | — | — | EP | disclosed |
| EP-1695959-A1 | Compouds and methods for the inhibition of the expression of VCAM-1 | Atherogenics, Inc. (US) | 2006-08-30 | — | — | EP | disclosed |
| US-20050171028-A1 | Thioketals and thioethers for inhibiting the expression of VCAM-1 | ATHEROGENICS PHARMACEUTICALS, INC. | 2005-08-04 | — | — | US | disclosed |
| US-20050090487-A1 | Compounds and methods for the inhibition of the expression of VCAM-1 | ATHEROGENICS, INC. | 2005-04-28 | — | — | US | disclosed |
| US-6852878-B2 | Thioketals and thioethers for inhibiting the expression of VCAM-1 | ATHEROGENICS, INC. (US) | 2005-02-08 | — | — | US | disclosed |
| EP-1468989-A2 | Compounds and methods for the inhibition of the expression of VCAM-1 | Atherogenics, Inc. (US) | 2004-10-20 | — | — | EP | disclosed |
| EP-1464639-A1 | Succinic acid ester of probucol for the inhibition of the expression of VCAM-1 | Atherogenics, Inc. (US) | 2004-10-06 | — | — | EP | disclosed |
| EP-1289944-A2 | THIOKETALS AND THIOETHERS FOR INHIBITING THE EXPRESSION OF VCAM-1 | Atherogenics, Inc. (US) | 2003-03-12 | — | — | EP | disclosed |
| US-20020193446-A1 | Compounds and methods for the inhibition of the expression of VCAM-1 | CRABTREE ACQUISITION CO, LLC | 2002-12-19 | — | — | US | disclosed |
| US-20020188118-A1 | Compounds and methods for the inhibition of the expression of VCAM-1 | CRABTREE ACQUISITION CO, LLC | 2002-12-12 | — | — | US | disclosed |
| US-20020177717-A1 | Compounds and methods for the inhibition of the expression of VCAM-1 | CRABTREE ACQUISITION CO, LLC | 2002-11-28 | — | — | US | disclosed |
| US-20020169215-A1 | Compounds and methods for the inhibition of the expression of VCAM-1 | CRABTREE ACQUISITION CO, LLC | 2002-11-14 | — | — | US | disclosed |
| US-20020016300-A1 | Thioketals and thioethers for inhibiting the expression of VCAM-1 | CRABTREE ACQUISITION CO, LLC | 2002-02-07 | — | — | US | disclosed |
| WO-2001070757-A2 | THIOKETALS AND THIOETHERS FOR INHIBITING THE EXPRESSION OF VCAM-1 | ATHEROGENICS, INC. (US) | 2001-09-27 | — | — | WO | disclosed |
| US-6147250-A | TREATING DISEASES MEDIATED BY VASCULAR CELL ADHESION MOLECULE-1, INCLUDING CARDIOVASCULAR AND INFLAMMATORY DISEASES; SUCCINOBUCOL | ATHEROGENICS, INC. (US) | 2000-11-14 | — | — | US | disclosed |
| EP-0994853-A2 | COMPOUNDS AND METHODS FOR THE INHIBITION OF THE EXPRESSION OF VCAM-1 | Atherogenics, Inc. (US) | 2000-04-26 | — | — | EP | disclosed |
| WO-1998051662-A2 | COMPOUNDS AND METHODS FOR THE INHIBITION OF THE EXPRESSION OF VCAM-1 | ATHEROGENICS, INC. (US) | 1998-11-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020169215-A1 | Compounds and methods for the inhibition of the expression of VCAM-1 | VCAM1, ICAM1, SELL | XDH 1399/4885ALDH1A1 100/4885GABRA1 1428/4885 |
| US-20050171028-A1 | Thioketals and thioethers for inhibiting the expression of VCAM-1 | VCAM1, ICAM1, KCNT1 | XDH 1912/4885ALDH1A1 112/4885GABRA1 2224/4885 |
| US-20020193446-A1 | Compounds and methods for the inhibition of the expression of VCAM-1 | VCAM1, ICAM1, SELL | XDH 1399/4885ALDH1A1 100/4885GABRA1 1428/4885 |
| US-20080214660-A1 | Compounds and Methods for the Inhibition of the Expression of VCAM-1 | VCAM1, ICAM1, SELL | XDH 1399/4885ALDH1A1 100/4885GABRA1 1428/4885 |
| US-20020177717-A1 | Compounds and methods for the inhibition of the expression of VCAM-1 | VCAM1, ICAM1, SELL | XDH 1399/4885ALDH1A1 100/4885GABRA1 1428/4885 |
| US-20020016300-A1 | Thioketals and thioethers for inhibiting the expression of VCAM-1 | VCAM1, ICAM1, KCNT1 | XDH 1912/4885ALDH1A1 112/4885GABRA1 2224/4885 |
| US-20020188118-A1 | Compounds and methods for the inhibition of the expression of VCAM-1 | VCAM1, ICAM1, SELL | XDH 1399/4885ALDH1A1 100/4885GABRA1 1428/4885 |
| US-20050090487-A1 | Compounds and methods for the inhibition of the expression of VCAM-1 | VCAM1, ICAM1, SELL | XDH 1399/4885ALDH1A1 100/4885GABRA1 1428/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.