Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.50 |
| ▸ | HTR7 | P34969 | 1/20 | 0.50 |
| ▸ | HRH1 | P35367 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TERT | O14746 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11196977 | 0.84 | HTR1A (0.53) | HTR1AHTR7HRH1DRD3HTR2B | |
| SCHEMBL24684797 | 0.80 | HTR1A (0.51) | HTR1AHTR7HRH1DRD3HTR2B | |
| SCHEMBL31326934 | 0.79 | HPGD (0.51) | HTR1AHTR7HRH1DRD3HTR2B | |
| SCHEMBL3455464 | 0.76 | NPC1 (0.60) | ACHESMN1; SMN2MEN1KMT2ATP53 | |
| SCHEMBL3592341 | 0.75 | SMN1; SMN2 (0.52) | HTR1AHTR7HRH1DRD3HTR2B | |
| SCHEMBL1569172 | 0.74 | HTR1A (0.69) | HTR1ADRD3MAOB | |
| SCHEMBL2149893 | 0.73 | POLB (0.62) | POLBALDH1A1 | |
| SCHEMBL2149809 | 0.73 | — | — | |
| SCHEMBL9016847 | 0.73 | MEN1 (0.56) | MEN1KMT2AALDH1A1 | |
| SCHEMBL23828673 | 0.73 | S1PR1 (0.46) | MEN1KMT2ATERTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008007835-A1 | 2,4-QUINAZOLINE DERIVATIVES HAVING ACTIVITY TO T-TYPE CALCIUM CHANNEL AND PREPARATION METHOD THEREOF | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2008-01-17 | — | — | WO | disclosed |
| WO-2008007835-A1 | 2,4-QUINAZOLINE DERIVATIVES HAVING ACTIVITY TO T-TYPE CALCIUM CHANNEL AND PREPARATION METHOD THEREOF | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2008-01-17 | — | — | WO | disclosed |
| EP-1871376-A2 | INHIBITORS OF AKT ACTIVITY | Merck & Co., Inc. (US) | 2008-01-02 | — | — | EP | disclosed |
| WO-2007011290-A1 | Bronchorelaxing agents based on indol- and isoquinoline derivatives | RESPIRATORIUS AB (SE) | 2007-01-25 | — | — | WO | disclosed |
| WO-2006110638-A2 | INHIBITORS OF AKT ACTIVITY | MERCK & CO., INC. (US) | 2006-10-19 | — | — | WO | disclosed |