Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.50 |
| ▸ | AKT1 | P31749 | 1/20 | 0.46 |
| ▸ | TGM2 | P21980 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Urea SCHEMBL10868725 | 0.83 | TSHR (0.50) | TSHRALDH1A1CYP3A4MAPTHSD17B10 | |
| Biphenyl SCHEMBL7005540 | 0.81 | TSHR (0.55) | TSHRALDH1A1FGFR4AKT1TGM2 | |
| Biphenyl SCHEMBL1539344 | 0.81 | TSHR (0.55) | TSHRALDH1A1FGFR4AKT1TGM2 | |
| Diphenylether SCHEMBL28391769 | 0.80 | PARP10 (0.59) | TSHRALDH1A1FGFR4AKT1TGM2 | |
| Benzene SCHEMBL20788779 | 0.80 | ALDH1A1 (0.79) | TSHRALDH1A1FGFR4AKT1TGM2 | |
| Acrylamide SCHEMBL28066609 | 0.79 | ALDH1A1 (0.52) | TSHRALDH1A1FGFR4AKT1TGM2 | |
| Aniline SCHEMBL28168391 | 0.79 | TSHR (0.52) | TSHRALDH1A1FGFR4AKT1TGM2 | |
| Phenol SCHEMBL4024542 | 0.79 | TDP1 (0.52) | TSHRALDH1A1FGFR4AKT1TGM2 | |
| Acrylamide SCHEMBL28163520 | 0.78 | TSHR (0.58) | TSHRALDH1A1FGFR4AKT1TGM2 | |
| Naphthalene SCHEMBL28218080 | 0.78 | ALDH1A1 (0.58) | TSHRALDH1A1FGFR4AKT1TGM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1889910-A2 | Systematic evolution of ligands by exponential enrichment: photoselection of nucleic acid ligands and solution selex | SomaLogic, Inc. (US) | 2008-02-20 | — | — | EP | disclosed |
| EP-0736105-B1 | SYSTEMATIC EVOLUTION OF LIGANDS BY EXPONENTIAL ENRICHMENT: PHOTOSELECTION OF NUCLEIC ACID LIGANDS | SOMALOGIC INC (US) | 2007-11-21 | — | — | EP | disclosed |
| US-20040132067-A1 | Systematic evolution of ligands by exponential enrichment: photoselection of nucleic acid ligands and solution selex | SOMALOGIC, INC. | 2004-07-08 | — | — | US | disclosed |
| US-6482594-B2 | Made by exposing nucleic acid candidate sequences having photoreactive groups to the target molecule, irradiating complexes formed to crosslink, and separating the crosslinked complexes and amplifying to give the ligands | SOMALOGIC, INC. | 2002-11-19 | — | — | US | disclosed |
| US-20020106652-A1 | Systematic evolution of ligands by exponential enrichment: photoselection of nucleic acid ligands and solution selex | SOMALOGIC, INC. | 2002-08-08 | — | — | US | disclosed |
| US-6291184-B1 | DETECTING TARGET MOLECULES IN A BIOLOGICAL SUBSTANCE ASSOCIATED WITH DISEASES BY EXPOSING SUBSTANCE TO A NUCLEIC ACID LIGAND THAT PHOTOCROSSLINKS TO A TARGET MOLECULE; IRRADIATING THE SUBSTANCE CONTAINING LIGAND, DETECT COMPLEXES | SOMALOGIC, INC. | 2001-09-18 | — | — | US | disclosed |
| US-6001577-A | SCREENING FOR LIGANDS ASSOCIATED WITH A DISEASE BY DETECTING LIGAND THAT PHOTOCROSSLINKS TO TARGET WITH PHOTOREACTIVE GROUPS FROM CANDIDATE MIXTURE, REMOVING ANY NUCLEIC ACIDS WITH AFFINITIES NOT ASSOCIATED WITH DISEASE, AND AMPLIFYING | NEXSTAR PHARMACEUTICALS, INC. (US) | 1999-12-14 | — | — | US | disclosed |
| EP-0736105-A4 | SYSTEMATIC EVOLUTION OF LIGANDS BY EXPONENTIAL ENRICHMENT: PHOTOSELECTION OF NUCLEIC ACID LIGANDS AND SOLUTION SELEX | UNIV RESEARCH CORP (US) | 1998-10-28 | — | — | EP | disclosed |
| US-5763177-A | SELEX IS AN ACRONYM FOR SYSTEMATIC EVOLUTION OF LIGANDS BY EXPONENTIAL ENRICHMENT; USEFUL FOR DIAGNOSIS AND/OR TREATMENT OF DISEASES OR PATHOLOGICAL OR TOXIC STATES | NEXSTAR PHARMACEUTICALS, INC. (US) | 1998-06-09 | — | — | US | disclosed |
| US-5567588-A | Systematic evolution of ligands by exponential enrichment: Solution SELEX | UNIVERSITY RESEARCH CORPORATION (US) | 1996-10-22 | — | — | US | disclosed |
| EP-0736105-A1 | SYSTEMATIC EVOLUTION OF LIGANDS BY EXPONENTIAL ENRICHMENT: PHOTOSELECTION OF NUCLEIC ACID LIGANDS AND SOLUTION SELEX | NeXstar Pharmaceuticals, Inc. (US) | 1996-10-09 | — | — | EP | disclosed |
| WO-1995008003-A1 | SYSTEMATIC EVOLUTION OF LIGANDS BY EXPONENTIAL ENRICHMENT: PHOTOSELECTION OF NUCLEIC ACID LIGANDS AND SOLUTION SELEX | UNIVERSITY RESEARCH CORPORATION (US) | 1995-03-23 | — | — | WO | disclosed |