Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5011831 | 0.87 | PTPN1 (0.48) | PTPN1KMT2ANPSR1MAPTHDAC3 | |
| SCHEMBL5011271 | 0.76 | PTPN1 (0.51) | PTPN1KMT2ANPSR1MAPTNAMPT | |
| SCHEMBL5014676 | 0.75 | PTPN1 (0.56) | PTPN1KMT2ANPSR1MAPTNAMPT | |
| SCHEMBL14734057 | 0.73 | KMT2A (0.78) | PTPN1KMT2AMAPTNAMPTTSHR | |
| Hydrochloric Acid SCHEMBL5794594 | 0.72 | KMT2A (0.76) | PTPN1KMT2AMAPTNAMPTTSHR | |
| SCHEMBL4490301 | 0.71 | HSD11B1 (0.43) | HDAC3 | |
| SCHEMBL24251873 | 0.71 | KMT2A (0.71) | KMT2AL3MBTL1MEN1GAATP53 | |
| SCHEMBL12341489 | 0.71 | NAMPT (0.51) | KMT2ANPSR1MAPTNAMPTL3MBTL1 | |
| SCHEMBL5011692 | 0.71 | PTPN1 (0.58) | PTPN1KMT2ANPSR1MAPTNAMPT | |
| SCHEMBL5009744 | 0.70 | DHODH (0.50) | PTPN1KMT2ANPSR1MAPTHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893562-A1 | REVERSIBLE INHIBITORS OF MONOAMINE OXIDASE A AND B | Merck Frosst Canada Ltd. (CA) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006133559-A1 | REVERSIBLE INHIBITORS OF MONOAMINE OXIDASE A AND B | MERCK FROSST CANADA LTD. (CA) | 2006-12-21 | — | — | WO | disclosed |