Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 6/20 | 0.41 |
| ▸ | DRD2 | P14416 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 3/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5011858 | 0.88 | DRD4 (0.44) | DRD4DRD2LMNADRD3FAAH | |
| SCHEMBL5016084 | 0.84 | ALDH1A1 (0.50) | DRD4DRD2LMNAHTTDRD3 | |
| SCHEMBL2098329 | 0.83 | TP53 (0.38) | LMNAHTTTP53SMN1; SMN2HTR1A | |
| SCHEMBL27644612 | 0.78 | DRD4 (0.41) | DRD4DRD2LMNAHTTDRD3 | |
| SCHEMBL5016098 | 0.74 | PIK3C2B (0.46) | DRD4DRD2LMNAHTTDRD3 | |
| SCHEMBL5536329 | 0.73 | DRD4 (0.61) | DRD4DRD2LMNAHTTDRD3 | |
| SCHEMBL2098328 | 0.71 | TP53 (0.38) | LMNAHTTTP53SMN1; SMN2HTR1A | |
| SCHEMBL5016096 | 0.70 | ALDH1A1 (0.43) | DRD4DRD2LMNAHTTDRD3 | |
| SCHEMBL27666181 | 0.69 | ALDH1A1 (0.48) | DRD4DRD2LMNADRD3POLB | |
| SCHEMBL5536324 | 0.68 | DRD4 (0.57) | DRD4DRD2DRD3FAAHPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678185-B1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMA CO LTD (JP) | 2008-10-08 | — | — | EP | disclosed |