Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C2B | O00750 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 7/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5016097 | 0.88 | KDM4E (0.44) | PIK3C2BKDM4EALDH1A1POLBHTT | |
| SCHEMBL27645146 | 0.82 | KDM4E (0.47) | KDM4EALDH1A1POLBHTTCYP2A13 | |
| SCHEMBL5011868 | 0.74 | DRD4 (0.41) | KDM4EALDH1A1POLBHTTDRD2 | |
| SCHEMBL5535773 | 0.73 | KDM4E (0.61) | KDM4EALDH1A1POLBHTTCYP2A13 | |
| SCHEMBL5016084 | 0.72 | ALDH1A1 (0.50) | KDM4EALDH1A1HTTDRD2DRD4 | |
| SCHEMBL5013397 | 0.69 | DRD2 (0.36) | DRD2DRD4DRD3HSP90AA1KMT2A | |
| SCHEMBL5535766 | 0.68 | KDM4E (0.61) | KDM4EALDH1A1POLBHTTCYP2A13 | |
| SCHEMBL27645184 | 0.66 | DRD2 (0.48) | DRD2DRD4DRD3MAPT | |
| SCHEMBL1281671 | 0.65 | PIK3C2B (0.81) | PIK3C2B | |
| SCHEMBL2107499 | 0.65 | ALDH1A1 (0.96) | KDM4EALDH1A1POLBHTTCYP2A13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678185-B1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMA CO LTD (JP) | 2008-10-08 | — | — | EP | disclosed |