Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.42 |
| ▸ | PPARG | P37231 | 2/20 | 0.42 |
| ▸ | HTR2B | P41595 | 2/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.42 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MLNR | O43193 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4729358 | 0.86 | ABCB11 (0.47) | AGTR2CYP3A4ADORA3ADRA2BSLC6A2 | |
| SCHEMBL1653406 | 0.77 | AGTR2 (0.62) | AGTR2CYP3A4ADORA3ADRA2BSLC6A2 | |
| SCHEMBL683298 | 0.77 | AGTR2 (0.62) | AGTR2CYP3A4ADORA3ADRA2BSLC6A2 | |
| SCHEMBL9193450 | 0.76 | AGTR2 (0.51) | AGTR2CYP3A4ADORA3ADRA2BSLC6A2 | |
| SCHEMBL14544772 | 0.75 | AGTR2 (0.60) | AGTR2CYP3A4ADORA3ADRA2BSLC6A2 | |
| SCHEMBL9194756 | 0.75 | AGTR2 (0.52) | AGTR2CYP3A4ADORA3ADRA2BSLC6A2 | |
| SCHEMBL682490 | 0.75 | AGTR2 (0.54) | AGTR2CYP3A4ADORA3ADRA2BSLC6A2 | |
| SCHEMBL9194556 | 0.75 | AGTR2 (0.52) | AGTR2CYP3A4ADORA3ADRA2BSLC6A2 | |
| SCHEMBL3974380 | 0.75 | AGTR2 (0.50) | AGTR2CYP3A4ADORA3ADRA2BSLC6A2 | |
| SCHEMBL683301 | 0.75 | AGTR2 (0.55) | AGTR2CYP3A4ADORA3ADRA2BSLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7378108-B1 | Percutaneous absorption preparation of compound having angiotensin II antagonistic activity | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-05-27 | — | — | US | disclosed |
| EP-1306089-B1 | Combination of benzimidazoles having angiotensin-II antagonistic activity with diuretics | TAKEDA PHARMACEUTICAL (JP) | 2007-09-05 | — | — | EP | disclosed |
| US-6348481-B2 | COMPOUND SUCH AS 1-(CYCLOHEXYLOXYCARBONYLOXY)ETHYL 2-ETHOXY-1-((2'-(1H-TETRAZOL-5-YL)BIPHENYL-4-YL)METHYL)-1H-BENZIMIDAZOLE-7 -CARBOXYLATE, WITH A COMPOUND HAVING DIURETIC ACTIVITY OR A COMPOUND HAVING CALCIUM ANTAGONISTIC ACTIVITY | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-02-19 | — | — | US | disclosed |
| US-6319938-B1 | PROPHYLAXIS OR TREATMENT OF DIABETIC NEPHROPHATHY OR GLOMERULOMONEPHRITIS BY ADMINISTERING BIPHENYL-SUBSTITUTED 2-SUBSTITUTED BENZIMIDAZOLE-4-CARBOXYLIC ACID OR ESTER | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-11-20 | — | — | US | disclosed |