Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5012018 | 0.86 | AGTR2 (0.42) | ABCB11EGFRERBB2CYP3A4ADORA3 | |
| SCHEMBL9199697 | 0.81 | — | — | |
| SCHEMBL15525727 | 0.81 | AGTR2 (0.50) | ABCB11EGFRERBB2CYP3A4ADORA3 | |
| SCHEMBL8328346 | 0.81 | CHRM1 (0.55) | — | |
| SCHEMBL9197386 | 0.81 | ABCB11 (0.56) | ABCB11EGFRERBB2CYP3A4ADORA3 | |
| SCHEMBL4793837 | 0.81 | CYP11B1 (0.58) | AGTR1AGTR2 | |
| SCHEMBL9192715 | 0.80 | CYP11B1 (0.59) | — | |
| Candesartan SCHEMBL3938 | 0.80 | AGTR1 (0.73) | ABCB11EGFRERBB2CYP3A4ADORA3 | |
| Candesartan SCHEMBL19357208 | 0.80 | AGTR1 (0.73) | ABCB11EGFRERBB2CYP3A4ADORA3 | |
| Candesartan SCHEMBL29508236 | 0.80 | AGTR1 (0.73) | ABCB11EGFRERBB2CYP3A4ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008035360-A2 | NOVEL CRYSTALLINE FORMS OF CANDESARTAN CILEXETIL, CANDESARTAN, TRITYLATED CANDESARTAN AND TRITYLATED CANDESARTAN CILEXETIL | ALEMBIC LIMITED (IN) | 2008-03-27 | — | — | WO | claimed |
| US-6608210-B2 | Such as 1-(cyclohexyloxycarbonyloxy)ethyl-2-ethoxy-1-((2'-(1H-tetrazol-t-yl)biphenyl-4-yl)methyl) benzimidazol-7-carboxylate; exhibits antihypertensive activity and strong angiotensin II antagonistic activity | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-08-19 | — | — | US | disclosed |
| US-6432996-B1 | ADMINISTERING BENZIMIDAZOLE DERIVATIVE ANGIOTENSIN II ANTAGONIST, INDANE DERIVATIVE ANGIOTENSIN CONVERTING ENZYME INHIBITOR, AND PYRIDINE DERIVATIVE HMG-CO A REDUCTASE INHIBITOR TO TREAT PROSTPRANDIAL HYPERGLYCEMIA IN DIABETES | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-08-13 | — | — | US | disclosed |
| US-6420405-B2 | MIXTURE WITH DIURETIC | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| US-6228874-B1 | 1-(BIPHENYL-4-YL)METHYL-1H-BENZIMIDAZOLE-7-CARBOXYLATE DERIVATIVE MIXTURE WITH FUROSEMIDE; SIDE EFFECT REDUCTION; DIURETICS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-08 | — | — | US | disclosed |