Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 6/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 2/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5014417 | 1.00 | TRPV1 (0.41) | TRPV1EPHX2CNR1CNR2MAPT | |
| SCHEMBL5015806 | 0.95 | TRPM8 (0.40) | TRPV1EPHX2TRPM8F2F10 | |
| SCHEMBL5012817 | 0.95 | FAAH (0.39) | TRPV1CNR2MAPTFAAHNPC1 | |
| SCHEMBL5012816 | 0.93 | FPR1 (0.40) | TRPV1EPHX2TRPM8F2F10 | |
| SCHEMBL5015689 | 0.93 | KMT2A (0.43) | MAPTFAAHNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL5014416 | 0.92 | TRPM8 (0.42) | TRPV1EPHX2TRPM8FAAHRAB9A | |
| SCHEMBL5014386 | 0.92 | KMT2A (0.39) | TRPV1MAPTFAAH | |
| SCHEMBL5012959 | 0.92 | KMT2A (0.39) | TRPV1MAPTFAAH | |
| SCHEMBL5015764 | 0.91 | TRPV1 (0.46) | TRPV1EPHX2MAPTTRPM8SMN1; SMN2 | |
| SCHEMBL5014470 | 0.91 | ABCG2 (0.42) | MAPTF2F10PRSS1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | claimed |
| EP-1888596-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2008-02-20 | — | — | EP | claimed |
| WO-2006122770-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2006-11-23 | — | — | WO | claimed |
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | disclosed |