Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 3/20 | 0.43 |
| ▸ | F2 | P00734 | 2/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.38 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5012860 | 0.96 | HTT (0.41) | F10F2PRSS1KMT2AKDM4E | |
| SCHEMBL5012280 | 0.95 | KMT2A (0.45) | F10F2PRSS1KMT2AKDM4E | |
| SCHEMBL5014511 | 0.93 | KDM4E (0.46) | KDM4EHTT | |
| SCHEMBL5012275 | 0.93 | KMT2A (0.39) | F10F2PRSS1KMT2AKDM4E | |
| SCHEMBL5014495 | 0.93 | CACNA1H (0.42) | KMT2AKDM4E | |
| SCHEMBL5012261 | 0.93 | KMT2A (0.46) | F10F2PRSS1KMT2AKDM4E | |
| SCHEMBL5012225 | 0.93 | KMT2A (0.46) | F10F2PRSS1KMT2AKDM4E | |
| SCHEMBL5012848 | 0.92 | FAAH (0.42) | F10F2PRSS1KMT2AKDM4E | |
| SCHEMBL5015832 | 0.91 | KDM4E (0.50) | KMT2AKDM4EHTT | |
| SCHEMBL5012241 | 0.91 | ALDH1A1 (0.43) | KDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | claimed |
| EP-1888596-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2008-02-20 | — | — | EP | claimed |
| WO-2006122770-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2006-11-23 | — | — | WO | claimed |
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | disclosed |