Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.52 |
| ▸ | HTR1A | P08908 | 8/20 | 0.51 |
| ▸ | HTR2C | P28335 | 4/20 | 0.51 |
| ▸ | CETP | P11597 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | DRD1 | P21728 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | DRD5 | P21918 | 1/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5013286 | 0.91 | HTR1A (0.51) | SIGMAR1HTR1AHTR2CCETPSLC6A4 | |
| SCHEMBL5016189 | 0.89 | HTR1A (0.49) | SIGMAR1HTR1AHTR2CCETPSLC6A4 | |
| SCHEMBL2093048 | 0.85 | LRRK2 (0.38) | SIGMAR1HTR1AHTR2CCETPSLC6A4 | |
| SCHEMBL27665756 | 0.81 | SIGMAR1 (0.55) | SIGMAR1HTR1AHTR2CCETPSLC6A4 | |
| SCHEMBL5539608 | 0.79 | SIGMAR1 (0.58) | SIGMAR1HTR1AHTR2CSLC6A4SLC6A2 | |
| SCHEMBL5012696 | 0.78 | SIGMAR1 (0.46) | SIGMAR1HTR1AHTR2CSLC6A4ADRA1D | |
| SCHEMBL5541921 | 0.78 | SIGMAR1 (0.57) | SIGMAR1HTR1AHTR2CSLC6A4SLC6A2 | |
| SCHEMBL5537510 | 0.78 | SIGMAR1 (0.57) | SIGMAR1HTR1AHTR2CSLC6A4SLC6A2 | |
| SCHEMBL27666215 | 0.77 | SIGMAR1 (0.55) | SIGMAR1HTR1AHTR2CCETPSLC6A4 | |
| SCHEMBL2094724 | 0.77 | HTR1A (0.37) | SIGMAR1HTR1AHTR2CCETPSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678185-B1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMA CO LTD (JP) | 2008-10-08 | — | — | EP | disclosed |