Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 8/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.35 |
| ▸ | KCNK10 | P57789 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GALR3 | O60755 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5015186 | 0.90 | SLC6A9 (0.43) | ALDH1A1POLBLMNAKMT2AMAPT | |
| SCHEMBL5015178 | 0.87 | MAPT (0.47) | ALDH1A1POLBLMNAKMT2AMAPT | |
| SCHEMBL1086868 | 0.86 | ALDH1A1 (0.41) | ALDH1A1POLBLMNAKMT2AMAPT | |
| SCHEMBL5016300 | 0.83 | SLC6A9 (0.43) | ALDH1A1POLBLMNAKMT2AMAPT | |
| SCHEMBL1086411 | 0.82 | ALDH1A1 (0.40) | ALDH1A1POLBLMNAKMT2AMAPT | |
| SCHEMBL1086551 | 0.81 | TACR1 (0.42) | KMT2ANPC1 | |
| SCHEMBL1086300 | 0.79 | HTT (0.38) | ALDH1A1POLBLMNAMAPTSMN1; SMN2 | |
| SCHEMBL1086423 | 0.79 | TACR2 (0.39) | — | |
| SCHEMBL1086626 | 0.78 | ALDH1A1 (0.41) | ALDH1A1POLBLMNAKMT2AMAPT | |
| SCHEMBL1086255 | 0.78 | ALDH1A1 (0.41) | ALDH1A1POLBLMNAKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910381-A2 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007000325-A2 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2007-01-04 | — | — | WO | disclosed |