Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 3/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1085995 | 0.87 | EPHX2 (0.47) | EPHX2ALDH1A1KMT2AMAPTALOX15 | |
| SCHEMBL1086626 | 0.87 | ALDH1A1 (0.41) | SLC6A9ALDH1A1LMNAKMT2ASLC6A5 | |
| SCHEMBL5015186 | 0.87 | SLC6A9 (0.43) | SLC6A9EPHX2ALDH1A1LMNAKMT2A | |
| SCHEMBL1086255 | 0.86 | ALDH1A1 (0.41) | SLC6A9ALDH1A1LMNAKMT2ASLC6A5 | |
| SCHEMBL1086866 | 0.83 | EPHX2 (0.44) | EPHX2ALDH1A1KMT2AMAPTALOX15 | |
| SCHEMBL5012782 | 0.83 | ALDH1A1 (0.39) | ALDH1A1LMNAKMT2APOLBGAA | |
| SCHEMBL5015178 | 0.82 | MAPT (0.47) | SLC6A9ALDH1A1LMNAKMT2ASLC6A5 | |
| SCHEMBL1086868 | 0.82 | ALDH1A1 (0.41) | ALDH1A1LMNAKMT2APOLBGAA | |
| SCHEMBL1086411 | 0.81 | ALDH1A1 (0.40) | SLC6A9ALDH1A1LMNAKMT2AMAPK1 | |
| SCHEMBL1086455 | 0.80 | ALDH1A1 (0.45) | EPHX2ALDH1A1LMNAKMT2AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910381-A2 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007000325-A2 | SUBSTITUTED 1-OXA-3,8-DIAZASPIRO[4.5]-DECAN-2-ON- COMPOUNDS AND THE USE THEREOF FOR PRODUCING DRUGS | Grünenthal GmbH (DE) | 2007-01-04 | — | — | WO | disclosed |