Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5012236 | 0.94 | GAA (0.42) | KMT2ARECQLGAAMEN1SMN1; SMN2 | |
| SCHEMBL16175756 | 0.91 | L3MBTL1 (0.41) | KMT2ARECQLGAAMEN1SMN1; SMN2 | |
| SCHEMBL5012815 | 0.91 | CHRM3 (0.39) | KMT2ARECQLGAAMEN1SMN1; SMN2 | |
| SCHEMBL5012814 | 0.90 | KMT2A (0.42) | KMT2AMEN1SMN1; SMN2KDM4EPKM | |
| SCHEMBL5012271 | 0.89 | CHRM3 (0.38) | KMT2ARECQLGAAMEN1SMN1; SMN2 | |
| SCHEMBL5012789 | 0.88 | PYGM (0.41) | KMT2ARECQLGAAMEN1PKM | |
| SCHEMBL5121952 | 0.88 | S1PR2 (0.47) | KMT2ARECQLGAAMEN1SMN1; SMN2 | |
| SCHEMBL5012813 | 0.88 | MAPT (0.42) | KMT2AGAASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL5014388 | 0.87 | KMT2A (0.43) | KMT2A | |
| SCHEMBL16175752 | 0.85 | KMT2A (0.42) | KMT2AGAAMEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | claimed |
| EP-1888596-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2008-02-20 | — | — | EP | claimed |
| WO-2006122770-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2006-11-23 | — | — | WO | claimed |
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | disclosed |