Known targets — ChEMBL curated mechanism
DRD2DRD3DRD4GNRHRHRH1HTR2AHTR2CSLC6A2SLC6A4SSTR1SSTR2SSTR3SSTR5
The experimentally established mechanism targets of Pamoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.83 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.83 |
| ▸ | ME2 | P23368 | 1/20 | 0.65 |
| ▸ | ME1 | P48163 | 1/20 | 0.65 |
| ▸ | ME3 | Q16798 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 8/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.52 |
| ▸ | MAPT | P10636 | 6/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.48 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.47 |
| ▸ | GALK1 | P51570 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pamoic Acid SCHEMBL5014430 | 0.97 | POLB (0.83) | POLBGPR35ME2ME1ME3 | |
| Pamoic Acid SCHEMBL248780 | 0.94 | GPR35 (0.71) | POLBGPR35ME2ME1ME3 | |
| Pamoic Acid SCHEMBL8894325 | 0.93 | GPR35 (0.69) | POLBGPR35ME2ME1ME3 | |
| Pamoic Acid SCHEMBL1457853 | 0.91 | GPR35 (0.71) | POLBGPR35ME2ME1ME3 | |
| Pamoic Acid SCHEMBL587128 | 0.91 | GPR35 (0.71) | POLBGPR35ME2ME1ME3 | |
| Pamoic Acid SCHEMBL11315960 | 0.91 | GPR35 (0.71) | POLBGPR35ME2ME1ME3 | |
| Pamoic Acid SCHEMBL517728 | 0.91 | GPR35 (0.71) | POLBGPR35ME2ME1ME3 | |
| Pamoic Acid SCHEMBL5420259 | 0.91 | GPR35 (0.71) | POLBGPR35ME2ME1ME3 | |
| Pamoic Acid SCHEMBL11812243 | 0.91 | GPR35 (0.94) | POLBGPR35ME2ME1ME3 | |
| Pamoic Acid SCHEMBL5721 | 0.91 | GPR35 (1.00) | POLBGPR35ME2ME1ME3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648338-A1 | COMPOSITE ABSORBABLE/BIODEGRADABLE RINGS FOR CONTROLLED DRUG DELIVERY | Poly-Med, Inc. (US) | 2006-04-26 | — | — | EP | claimed |
| WO-2005002471-A1 | COMPOSITE ABSORBABLE/BIODEGRADABLE RINGS FOR CONTROLLED DRUG DELIVERY | POLY-MED, INC. (US) | 2005-01-13 | — | — | WO | claimed |
| US-20040265355-A1 | Composite absorbable/biodegradable rings for controlled drug delivery | POLY-MED, INC. | 2004-12-30 | — | — | US | claimed |
| WO-2008138783-A1 | EXPOSURE AGENT FOR DETECTION OF VITAMIN D | NORDIC BOISCIENCE A/S (DK) | 2008-11-20 | — | — | WO | disclosed |
| US-5723467-A | Method of treating psychotic disorders using risperidone pamoate | JANSSEN PHARMACEUTICA, N.V. (BE) | 1998-03-03 | — | — | US | disclosed |
| EP-0697019-B1 | RISPERIDONE PAMOATE | JANSSEN PHARMACEUTICA NV (BE) | 1998-02-25 | — | — | EP | disclosed |
| US-5612346-A | ANTIPSYCHOTIC AGENTS | JANSSEN PHARMACEUTICA N.V. (BE) | 1997-03-18 | — | — | US | disclosed |
| EP-0697019-A1 | RISPERIDONE PAMOATE | JANSSEN PHARMACEUTICA N.V. (BE) | 1996-02-21 | — | — | EP | disclosed |
| WO-1994025460-A1 | RISPERIDONE PAMOATE | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-11-10 | — | — | WO | disclosed |