Known targets — ChEMBL curated mechanism
DRD2DRD3DRD4GNRHRHRH1HTR2AHTR2CSLC6A2SLC6A4SSTR1SSTR2SSTR3SSTR5
The experimentally established mechanism targets of Pamoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.71 |
| ▸ | POLB | P06746 | 1/20 | 0.71 |
| ▸ | ME2 | P23368 | 1/20 | 0.56 |
| ▸ | ME1 | P48163 | 1/20 | 0.56 |
| ▸ | ME3 | Q16798 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pamoic Acid SCHEMBL248780 | 0.97 | GPR35 (0.71) | GPR35POLBME2ME1ME3 | |
| Pamoic Acid SCHEMBL1457853 | 0.97 | GPR35 (0.71) | GPR35POLBME2ME1ME3 | |
| Pamoic Acid SCHEMBL5420259 | 0.97 | GPR35 (0.71) | GPR35POLBME2ME1ME3 | |
| Pamoic Acid SCHEMBL517728 | 0.97 | GPR35 (0.71) | GPR35POLBME2ME1ME3 | |
| Pamoic Acid SCHEMBL11315960 | 0.97 | GPR35 (0.71) | GPR35POLBME2ME1ME3 | |
| Pamoic Acid SCHEMBL8894325 | 0.95 | GPR35 (0.69) | GPR35POLBME2ME1ME3 | |
| Pamoic Acid SCHEMBL5012893 | 0.91 | POLB (0.83) | GPR35POLBME2ME1ME3 | |
| Pamoic Acid SCHEMBL5014430 | 0.91 | POLB (0.83) | GPR35POLBME2ME1ME3 | |
| Pamoic Acid SCHEMBL5721 | 0.83 | GPR35 (1.00) | GPR35POLBME2ME1ME3 | |
| Pamoic Acid SCHEMBL446833 | 0.83 | GPR35 (1.00) | GPR35POLBME2ME1ME3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180161365-A1 | Phosphate-Binding Magnesium Salts And Uses Thereof | CURRAX PHARMACEUTICALS LLC | 2018-06-14 | — | — | US | claimed |
| US-9889157-B2 | Phosphate-binding magnesium salts and uses thereof | CYPRESS PHARMACEUTICALS, INC. (US) | 2018-02-13 | — | — | US | claimed |
| US-20170202875-A1 | Phosphate-Binding Magnesium Salts And Uses Thereof | WILMINGTON SAVINGS FUND SOCIETY, FSB | 2017-07-20 | — | — | US | claimed |
| US-9610267-B2 | Phosphate-binding magnesium salts and uses thereof | CYPRESS PHARMACEUTICALS, INC. (US) | 2017-04-04 | — | — | US | claimed |
| US-20160256420-A1 | Phosphate-Binding Magnesium Salts And Uses Thereof | WILMINGTON SAVINGS FUND SOCIETY, FSB | 2016-09-08 | — | — | US | claimed |
| US-9339481-B2 | Phosphate-binding magnesium salts and uses thereof | CYPRESS PHARMACEUTICALS, INC. (US) | 2016-05-17 | — | — | US | claimed |
| EP-2416786-A1 | PHOSPHATE-BINDING MAGNESIUM SALTS AND USES THEREOF | Cypress Pharmaceutical, Inc. (US) | 2012-02-15 | — | — | EP | claimed |
| WO-2010117370-A1 | PHOSPHATE-BINDING MAGNESIUM SALTS AND USES THEREOF | CYPRESS PHARMACEUTICALS, INC. (US) | 2010-10-14 | — | — | WO | claimed |
| US-20090269399-A1 | PHOSPHATE-BINDING MAGNESIUM SALTS AND USES THEREOF | CYPRESS PHARMACEUTICAL, INC. (US) | 2009-10-29 | — | — | US | claimed |
| US-4291026-A | ISOLATION FROM MASH BY COMPLEXING WITH SALTS; ANIMAL FEEDS | AMERICAN CYANAMID COMPANY (US) | 1981-09-22 | — | — | US | claimed |
| EP-0024508-A2 | Antibiotic BM123-gamma pamoate complexes, process for their preparation and compositions containing them | AMERICAN CYANAMID COMPANY (US) | 1981-03-11 | — | — | EP | claimed |
| WO-2021237039-A1 | COMPOSITIONS AND METHODS FOR LONG TERM RELEASE OF GONADOTROPIN-RELEASING HORMONE (GNRH) ANTAGONISTS | VERU INC. (US) | 2021-11-25 | — | — | WO | disclosed |
| CN-113166058-A | Fluoro beta-carboline compounds | 奥斯特克有限公司 | 2021-07-23 | — | — | CN | disclosed |
| CN-112996506-A | Pyrrolodipyridine compounds | 奥斯特克有限公司 | 2021-06-18 | — | — | CN | disclosed |
| US-20200282008-A1 | COMPOSITIONS AND METHODS FOR LONG TERM RELEASE OF GONADOTROPIN-RELEASING HORMONE (GnRH) ANTAGONISTS | VERU, INC. | 2020-09-10 | — | — | US | disclosed |
| EP-2416786-A1 | PHOSPHATE-BINDING MAGNESIUM SALTS AND USES THEREOF | Cypress Pharmaceutical, Inc. (US) | 2012-02-15 | — | — | EP | disclosed |
| US-20110045063-A2 | PHOSPHATE-BINDING MAGNESIUM SALTS AND USES THEREOF | CYPRESS PHARMACEUTICAL, INC. (US) | 2011-02-24 | — | — | US | disclosed |
| WO-2010117370-A1 | PHOSPHATE-BINDING MAGNESIUM SALTS AND USES THEREOF | CYPRESS PHARMACEUTICALS, INC. (US) | 2010-10-14 | — | — | WO | disclosed |
| US-20090269399-A1 | PHOSPHATE-BINDING MAGNESIUM SALTS AND USES THEREOF | CYPRESS PHARMACEUTICAL, INC. (US) | 2009-10-29 | — | — | US | disclosed |
| US-4599359-A | POTENTIATION | Cooper, Stephen A. (US) | 1986-07-08 | — | — | US | disclosed |