Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H | O95180 | 7/20 | 0.42 |
| ▸ | CACNA1C | Q13936 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | SSTR5 | P35346 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5012290 | 0.93 | F10 (0.43) | KDM4EKMT2A | |
| SCHEMBL5012860 | 0.93 | HTT (0.41) | KDM4EKMT2A | |
| SCHEMBL16175669 | 0.90 | MAPT (0.40) | ALDH1A1SSTR5NPSR1KDM4EMEN1 | |
| SCHEMBL5012899 | 0.90 | KMT2A (0.46) | CACNA1HCACNA1CALDH1A1SSTR5MEN1 | |
| SCHEMBL5012261 | 0.90 | KMT2A (0.46) | CACNA1HCACNA1CKDM4EKMT2A | |
| SCHEMBL5012225 | 0.90 | KMT2A (0.46) | GAAFAAHKDM4EKMT2A | |
| SCHEMBL5014511 | 0.90 | KDM4E (0.46) | ALDH1A1KDM4E | |
| SCHEMBL5012275 | 0.90 | KMT2A (0.39) | KDM4EKMT2A | |
| SCHEMBL16175517 | 0.89 | USP2 (0.45) | ALDH1A1FAAHKDM4E | |
| SCHEMBL5015785 | 0.89 | FAAH (0.43) | FAAHKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | claimed |
| EP-1888596-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2008-02-20 | — | — | EP | claimed |
| WO-2006122770-A1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | Grünenthal GmbH (DE) | 2006-11-23 | — | — | WO | claimed |
| EP-1888596-B1 | SUBSTITUTED SPIRO COMPOUNDS AND THEIR USE FOR PRODUCING PAIN-RELIEF MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2014-10-22 | — | — | EP | disclosed |